Using high-dose insulin therapy to enhance liver function before surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study aims to determine whether high-dose insulin therapy can improve liver function in patients scheduled for major liver surgery. Participants will undergo a 6-hour infusion of insulin and dextrose to maintain a hyperinsulinemic-normoglycemic state in the weeks leading up to their surgery. The study will assess the effects of this therapy on liver function and regeneration, particularly after a liver venous deprivation procedure, using 99m-Tc-Mebrofenin hepatobiliary scintigraphy. The research seeks to optimize the future liver remnant for better surgical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18 years old
* Candidate for major liver resection
* Resectable colorectal liver metastasis

Exclusion Criteria:

* Inability to give consent
* Type 1 diabetes mellitus
* Uncontrolled blood glucose levels (fasting level \> 10 mmol/L)
* Unresectable colorectal liver metastasis
* Extrahepatic metastatic disease that is unresectable

Where it's running

• McGill Univeristy Health Centre
  Montreal, Quebec, Canada Recruiting

Study contacts

• Study coordinator: Jennifer Kalil, MD
• Email: jennifer.kalil@mail.mcgill.ca
• Phone: 514-934-1934

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.