Guided bone regeneration using xenograft mixed with donor (allogenic) bone versus xenograft mixed with your own (autogenous) bone to rebuild upper jaw ridges

Radiographic And Histomorphometric Assessment Of Guided Bone Regeneration Using Xenograft Mixed With Allogenic Bone Graft Versus Xenograft Mixed With Autogenous Bone Graft For Augmentation Of Deficient Maxillary Alveolar Ridges A Randomized Clinical Trial

This will test whether mixing xenograft with donor bone works as well as mixing xenograft with a patient's own bone to rebuild narrow upper jaw ridges before implant placement.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 32 (estimated)
• Ages: 20 Years to 50 Years
• Sex: All
• Sponsor: Cairo University (other)
• Drugs / interventions: chemotherapy
• Locations: 1 site (Cairo)
• Trial ID: NCT07367464 on ClinicalTrials.gov

What this trial studies

The study will compare two grafting approaches for augmenting deficient maxillary ridges: xenograft mixed 1:1 with allogenic (donor) bone versus xenograft mixed 1:1 with autogenous (patient) bone. Eligible patients will undergo clinical and CBCT evaluation, then a full-thickness flap, decortication, placement of the assigned graft mixture, and coverage with a collagen pericardium membrane fixed with tacks. Outcomes include radiographic dimensional ridge changes measured on CBCT and histomorphometric analysis of newly formed bone. Participants will be recruited and treated at the Faculty of Dentistry, Cairo University, with standardized surgical and follow-up protocols.

Who should consider this trial

Good fit: Adults aged 20–50 with totally or partially edentulous maxillary ridges, residual alveolar width 2–4 mm, at least 10 mm vertical height, adequate inter-arch space, and otherwise medically healthy are the intended candidates.

Not a fit: Patients with vertical bone deficiency, pathological lesions at the site, uncontrolled systemic disease, medications that impair healing, recent chemo/radiotherapy, or habits like heavy alcohol use are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, patients might avoid harvesting their own bone while achieving similar ridge width and bone quality, reducing operative time and donor-site morbidity.

How similar studies have performed: Similar combinations of xenografts with autogenous or allogenic grafts have been used in guided bone regeneration with some studies reporting comparable volume gains but variable histologic outcomes, so the approach is not entirely novel and evidence is mixed.

Eligibility criteria

Inclusion Criteria:

* Age: 20-50 years.
* Totally or partially edentulous maxillary ridges.
* Patients with insufficient bone for an implant placement.
* Residual alveolar width ranging from 2 to 4 mm.
* Minimum of 10 mm vertical dimension to nasal floor or sinus floor.
* Patients with healthy systemic condition (Medically free).
* Adequate inter-arch space for placement of the implant prosthetic part.

Exclusion Criteria:

* Pathological lesions in the defect site.
* Systemic diseases that would interfere with bone metabolism. Uncontrolled diabetic patients.
* Ongoing treatment or a history of recent chemotherapy or radiotherapy.
* Patient with medical condition that contraindicates surgical procedures.
* Patients on medication that may interfere with healing (Corticosteroids, Bisphosphonate, Chemo/radio therapy).
* Patients with vertical bone deficiency.
* Patients with habits that may jeopardize the implant longevity and affect the results of the study such as alcoholism or para-functional habits.

Where this trial is running

Cairo

• Faculty of Dentistry Cairo University — Cairo, Egypt (RECRUITING)

Study contacts

• Principal investigator: Mohamed A. Abousetta, Bachelor — Cairo University
• Study coordinator: Mohamed A. Abousetta

Conditions: Guided Bone Regeneration, DFDBA, Autogenous Bone Graft, Xenograft, Xenograft Mixed With Autogenous Bone Graft, Xenograft Mixed With Allogenic Bone Graft, Deficient Maxillary Alveolar Ridges