Rebuilding bone in the lower back jaw with resorbable or non‑resorbable membranes
Comparative Evaluation of Resorbable (Pericardium) Versus Non Resorbable (Polytetrafluoroethylene) Membrane for Horizontal Bone Augmentation of Posterior Atrophic Mandible
This trial tests whether a resorbable pericardium membrane or a non‑resorbable PTFE membrane better helps rebuild horizontal bone in the lower back jaw for people who need bone grafting before dental implants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Beirut Arab University Academic / other |
| Locations | 1 site (Beirut) |
| Trial ID | NCT07254494 on ClinicalTrials.gov |
What this trial studies
Adults with horizontal bone loss in the posterior mandible will receive guided bone regeneration using either a resorbable pericardium membrane or a non‑resorbable PTFE membrane along with standard graft material. Outcomes such as horizontal bone gain, membrane exposure, infection, and readiness for implant placement will be tracked over follow‑up visits extending at least one year. The procedures follow routine surgical protocols for ridge augmentation and include perioperative care to minimize complications. Data will be compared between the two membrane groups to see which approach provides more predictable horizontal bone reconstruction.
Who should consider this trial
Good fit: Adults with an atrophic posterior mandibular alveolar ridge needing horizontal bone augmentation before implant placement, who have adequate residual bone height, good oral hygiene, and no systemic conditions that impair bone healing are ideal candidates.
Not a fit: Patients with vertical or complex defects, active local or systemic infections, heavy smokers, poor oral hygiene, pregnancy, or systemic diseases affecting bone healing are unlikely to benefit from this comparison.
Why it matters
Potential benefit: If successful, the better membrane option could provide more reliable horizontal bone gain and fewer complications, making implant placement easier and more predictable.
How similar studies have performed: Previous studies show both PTFE and resorbable membranes can support guided bone regeneration, with PTFE offering strong space maintenance but higher exposure and removal needs while resorbable pericardium often has fewer exposures, although direct head‑to‑head evidence is still limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mandibular posterior atrophic alveolar ridge Required horizontal bone augmentation procedures prior to implant placement. * Alveolar bone height suitable for implant placement. * Free of any local or systemic condition that may contraindicate ridge expansion procedure * The capacity to understand and accept the conditions of the study. * Continuing participation over at least 1 year of follow-up. Exclusion Criteria: * Heavy smokers (i.e., 2 or more packs of cigarettes per day); * Insufficient oral hygiene * Acute local or systemic infection * Patients with any systemic disease that may affect bone healing; * Pregnancy or the possibility of becoming pregnant during the study; and * Addiction to drugs or alcohol
Where this trial is running
Beirut
- Beirut arab university — Beirut, Lebanon (Recruiting)
Study contacts
- Study coordinator: hiba A alrifaii, BA
- Email: haa135@student.bau.edu.lb
- Phone: 96171693913
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.