Patterned repetitive TMS over the supplementary motor area for Parkinson's bradykinesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial delivers patterned repetitive transcranial magnetic stimulation (prTMS) targeted to the supplementary motor area (SMA) and compares active stimulation with a sham procedure. Participants with clinically established or probable Parkinson's disease who are stable on antiparkinsonian medication will receive sessions of either active or sham prTMS, with motor function measured before and after the intervention. The study excludes people with epilepsy risk, certain psychiatric medications, MRI or TMS contraindications, and pregnant participants. Results will focus on changes in bradykinesia severity and related motor measures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Above 18 years of age. Clinically established or probable Parkinson's Disease (PD), according to the Movement Disorder Society.

Clinical Diagnostic Criteria for PD. Stable antiparkinsonian medicine for at least four weeks. Signed informed consent.

Exclusion Criteria:

Psychiatric disorders. Current use of antipsychotic medication, Donepezil, or GABAergic agents (e.g., pregabalin, gabapentin).

Frequent benzodiazepine or opioid use defined as more than once per week on a regular basis.

History of neurological disease other than PD. Past or present mental illness. History of epilepsy/conditions associated with increased risk of seizure induction through transcranial magnetic stimulation (TMS).

Close relatives suffering from epilepsy/conditions associated with increased risk of seizures.

Contraindications for magnetic resonance imaging (MRI) Contraindications for TMS Female participants of childbearing age must not be pregnant and must use contraception during the trial.

Refuse to be informed about new health-related information and accidental health-related findings that might appear through participation in the study.

Where it's running

• Drcmr
  Hvidovre, Denmark Recruiting

Study contacts

• Study coordinator: Ann-Charlot Rughaven, M.Sc.
• Email: ann-charlot.rughaven@regionh.dk
• Phone: +4521123531

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.