Paravertebral Catheter Analgesia Versus Epidural Analgesia for Totally Minimally Invasive Esophagectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study compares two pain-management approaches in adults undergoing totally minimally invasive esophagectomy for esophageal cancer. Participants are assigned to receive either paravertebral catheter analgesia or thoracic epidural analgesia as part of multimodal analgesia. The trial focuses on postoperative pain, recovery markers, and safety in a real-world surgical setting. It leverages robot-assisted or non-robot-assisted minimally invasive techniques and standard adjuvant care. Results could inform pain management choices to optimize recovery after esophagectomy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient requiring totally minimally invasive surgical esophagectomy (robot-assisted or not) with 2 Ivor-Lewis type approaches: laparoscopy for the abdominal approach and thoracoscopy for the thoracic approach.
* Age ≥ 18 years old
* Patient who has given written consent to participate in the trial
* Socially insured patient
* Patient willing to comply with all study procedures and duration

Exclusion Criteria:

* \- Intervention planned by open esophagectomy (laparotomy and/or thoracotomy)
* 3-stage esophagectomy, McKeown type
* Obesity with body mass index ≥ 35 kg.m-2 (due to the foreseeable difficulties arising from this BMI).
* Pregnancy
* Haemostasis trouble
* ASA score \> 3
* Renal failure (eGFR \< 50 mL/min)
* Ongoing opioid use (\>3 months prior to the day of surgery)
* Contraindication to local anesthesia
* Local infection
* Inability to receive informed information
* Person deprived of the liberty
* Person benefiting from a system of legal protection (guardianship…)

Where it's running

• CHU de Lille
  Lille, France Recruiting

Study contacts

• Study coordinator: Cédric CIRENEI,, MD
• Email: cedric.cirenei@chru-lille.fr
• Phone: 03 20 44 59 62

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.