Orthograde vs retrograde MTA root-end filling after periapical surgery
Official title: To Evaluate and Compare the Effect of Orthograde and Retrograde MTA Root End Filling on Clinical, 2D and 3D Radiographic Success and Quality of Life After Periapical Surgery in Posteriors- A Randomised Control Trial
Run by Postgraduate Institute of Dental Sciences Rohtak · NCT07808424 · Data updated 2026-11-12
This trial tests whether orthograde MTA filling works as well as retrograde filling for healing after periapical surgery in back teeth with persistent symptomatic apical periodontitis.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 54 (estimated) |
| Sponsor | Postgraduate Institute of Dental Sciences Rohtak Academic / other |
| Locations | 1 site (Rohtak, Haryana) |
| Status | Recruiting |
| Started | April 29, 2026 |
| Main results expected | October 28, 2027 |
| Study ends | October 28, 2027 |
| Registry record updated | September 8, 2026 |
| Trial ID | NCT07808424 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-55 with non-vital posterior teeth and persistent symptomatic apical periodontitis requiring periapical surgery, meeting the inclusion criteria and with no major systemic health issues.
✕Probably not a fit
Patients with complex root anatomy, contraindications to oral surgery, or lesions not meeting size criteria may not see benefits from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares orthograde and retrograde mineral trioxide aggregate (MTA) root-end fillings performed during periapical micro-surgery in posterior teeth. Outcomes include clinical healing, 2D and 3D radiographic healing, and patient quality of life at one year. Eligible participants have non-vital/posterior teeth with persistent symptomatic apical periodontitis, suitable anatomy, and no major systemic disease. The study is conducted at the Postgraduate Institute of Dental Sciences Rohtak and aims to determine if a less invasive orthograde approach can match or surpass retrograde filling in effectiveness and patient-reported outcomes.
Why it matters
Potential benefit: If orthograde MTA is as effective or better, patients could experience similar healing with a less invasive procedure and improved comfort.
How similar studies have gone: Previous evidence supports MTA use in retrograde fillings; this study explores orthograde filling, which is less established in this context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients in which non-surgical retreatment is unfeasible (anatomical complexity, iatrogenic errors) or previously failed treatment in cases of persistent symptomatic apical periodontitis involving posteriors. * Tooth with a peri-radicular lesion of endodontic origin (chronic apical periodontitis) or endo-perio origin with the size of lesion ≥5mm. * Teeth with less than 10 degree root curvature. * Patients between 18-55 years of age. * No general medical contraindications for oral surgical procedures (ASA-1 according to the classification of the American Society of Anesthesiologists) * Tooth with adequate final restoration without clinical evidence of coronal leakage. * Good periodontal health condition at tooth level. * Able to completely understand and sign an informed consent form. Exclusion Criteria: * • Patients with systemic diseases (diabetes mellitus, uncontrolled hypertension grade III, hepatic/renal disease, or systemic bleeding disorders) (Bharathi et al 2021). * Patients on anticoagulant/ antiplatelet drugs. * Fractured/perforated teeth. * Presence of vertical root fracture. * Pregnancy.
Where it's running
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Pgids
Rohtak, Haryana, India Recruiting
Study contacts
- Study coordinator: Dr. SHWETA MITTAL, MDS
- Email: shwetagoelendo@gmail.com
- Phone: 9255596960
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.