Optimizing a non-invasive method to study auditory nerve function
Official title: Optimization of a Non-invasive Electrophysiological Method for Studying the Functionality of Auditory Nerve Fibers
Run by University Hospital, Clermont-Ferrand · NCT04198909 · Data updated 2026-11-12
This study is testing a new way to measure how well the auditory nerve works in healthy people to help find hidden hearing loss that regular tests might miss.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 55 Years |
| Sex | All |
| Enrollment | 220 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | April 29, 2019 |
| Main results expected | April 2028 |
| Study ends | April 2028 |
| Registry record updated | June 17, 2026 |
| Trial ID | NCT04198909 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are healthy volunteers aged 18 to 55 with normal hearing and no history of ear infections or noise exposure.
✕Probably not a fit
Patients with existing hearing complaints, ear infections, or significant medical histories may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to optimize a non-invasive electrophysiological method, specifically electrocochleography, to assess the functionality of auditory nerve fibers in healthy volunteers. The research focuses on understanding 'hidden hearing loss,' which may not be detected by conventional hearing tests. By refining the electrode assembly and acoustic stimulation techniques, the study seeks to establish normative values for wave I morphology in individuals without hearing disorders. This could lead to better diagnostic tools for identifying auditory nerve injuries.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive diagnostic tool for early detection of auditory nerve damage, improving patient outcomes.
How similar studies have gone: While the approach of using non-invasive electrocochleography is innovative, similar studies have shown promise in assessing auditory function, though this specific optimization is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Between 18 and 55 years old * be affiliated to a social security system * understand (oral and written) of the French language * be a qualified hearing with normal tympanogram and audiogram Exclusion Criteria: * have a complaint of hearing * have a exposure to noise (professional and/or activities) * refusal to participate in the study * have ear infections and/or ENT medical history * have cardiovascular, metabolic, neurological and psychiatric desease * being a protected person * healthy volunteer who has received compensation equal to or greader than 4500€ in clinical study
Where it's running
-
Chu Clermont Ferrand
Clermont-Ferrand, France Recruiting
Study contacts
- Principal investigator: Fabrice Giraudet — Université d'Auvergne
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: 334.73.754.963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.