Endothelial Function in Healthy Women Over 50 See How Your Blood Vessels Work
Official title: Endothelial Function in Healthy Volunteers (NormFMD)
Run by University Hospital, Clermont-Ferrand · NCT07837076 · Data updated 2026-11-12
This study tests whether flow-mediated dilation (FMD) measurements in healthy women aged 50 and older can establish reference values.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | Women only |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 1 site (Clermont-Ferrand) |
| Status | Recruiting |
| Started | October 5, 2026 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT07837076 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women aged 50 or older who are enrolled in a social security system and do not have a history of cardiovascular disease or other contraindicating conditions.
✕Probably not a fit
Individuals with cardiovascular disease or other disqualifying medical histories may not benefit from this reference-value study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers will measure endothelial function using FMD in healthy women 50+ to establish reference values and relate these measurements to muscle function and quality of life. The study aggregates observational and interventional insights from previous work to standardize methods and reduce biases. It is conducted at a single center in Clermont-Ferrand with a long-standing collaboration with INRAE and uses non-invasive FMD as the primary endpoint.
Why it matters
Potential benefit: If successful, the results could provide standardized reference values to help detect early endothelial dysfunction.
How similar studies have gone: Previous studies showed low FMD values in certain conditions, but these were retrospective with methodological variability; this study aims to provide standardized reference values.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women aged 50 or over. * Able to give informed consent to take part in the research. * Enrolled in a social security system. Exclusion Criteria: * A history of cardiovascular disease (myocardial infarction, arterial disease) deemed by the investigator to be incompatible with the trial. * Medical and/or surgical history deemed by the investigator to be incompatible with the trial. * Treatment with lipid-lowering drugs, for high blood pressure or osteoporosis. * Women under legal guardianship or deprived of their liberty. * Refusal to participate.
Where it's running
-
Clinical Investigation Platform/Clinical Investigation Center, Inserm CIC 1405
Clermont-Ferrand, France Recruiting
Study contacts
- Principal investigator: Gisèle Pickering — University Hospital, Clermont-Ferrand
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: +334754963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.