Impact of Phosphate Supplementation on FGF23 Levels in Hypophosphatemia Patients
Official title: Study of the Impact of Phosphate Supplementation on FGF23 Concentrations in Patients With Hypophosphatemia
Run by University Hospital, Clermont-Ferrand · NCT07827989 · Data updated 2026-11-12
This study tests whether giving phosphate affects FGF23 levels in adults with low phosphate who need supplementation.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University Hospital, Clermont-Ferrand Academic / other |
| Locations | 3 sites (Clermont-Ferrand and 2 other locations) |
| Status | Recruiting |
| Started | June 13, 2026 |
| Main results expected | May 2027 |
| Study ends | September 2027 |
| Registry record updated | September 18, 2026 |
| Trial ID | NCT07827989 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with hypophosphatemia (< 0.8 mmol/L) who are hospitalized in ICU, oncology, or rheumatology and have a clinical indication for phosphate supplementation.
✕Probably not a fit
Patients with kidney disease stage 3 or higher, active infection, pregnancy, current active vitamin D treatment, recent Ferinject therapy, or other exclusion criteria may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study examines how phosphate supplementation influences circulating FGF23 concentrations in adults with hypophosphatemia who are hospitalized for intensive care, oncology, or rheumatology care. FGF23 is a key regulator of phosphate balance, and prior data suggest intake changes alter its levels; however, data in hypophosphatemia are limited. The trial involves obtaining blood samples to measure FGF23 before and after phosphate administration to characterize the relationship between supplementation and hormone response. Eligible patients have low phosphate levels and a clinical need for supplementation, while several conditions (such as advanced kidney disease, active vitamin D therapy, or infection) exclude participation. Results could inform how phosphate therapy modulates phosphate homeostasis via FGF23 in this population.
Why it matters
Potential benefit: If successful, the study could clarify how phosphate therapy modulates FGF23, potentially guiding safer and more effective supplementation strategies.
How similar studies have gone: Previous data in X-linked hypophosphatemic rickets suggest phosphate supplementation can raise FGF23, but broader data in hypophosphatemia are limited, making this investigation relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients hospitalized in adult intensive care, oncology, or rheumatology * Hypophosphatemia \< 0.8 mmol/L * Clinical indication for phosphate supplementation Exclusion Criteria: * Chronic kidney disease, stage ≥ 3 (eGFR \< 60 mL/min/1.73 m²) * Treatment with Ferinject® within the past year * Sepsis * Current treatment with active vitamin D * Pregnancy or breastfeeding * Inability to perform blood draws due to insufficient venous access * Weight \< 35 kg (for intensive care patients only) * Hypercalcemia \> 2.6 mmol/L
Where it's running
-
CHU Clermont-Ferrand Service de réanimation
Clermont-Ferrand, France Recruiting -
CHU Clermont-Ferrand Service Oncologie
Clermont-Ferrand, France Recruiting -
CHU Clermont-Ferrand Service Rhumatologie
Clermont-Ferrand, France Recruiting
Study contacts
- Study coordinator: Lise Laclautre
- Email: promo_interne_drci@chu-clermontferrand.fr
- Phone: 0473754963
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.