AGE buildup in people starting long-term parenteral nutrition
Official title: Study of Advanced Glycation End-products Accumulation in Patients Under Long-Term Parenteral Nutrition (NUPARAGE2)
Run by University Hospital, Bordeaux · NCT07392801 · Data updated 2026-11-12
This study checks whether adults and kids starting long-term parenteral nutrition accumulate more advanced glycation end-products over a year by non-invasive skin measurements.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Hospital, Bordeaux Academic / other |
| Locations | 3 sites (Bordeaux and 2 other locations) |
| Status | Recruiting |
| Started | July 22, 2026 |
| Main results expected | July 2027 |
| Study ends | July 2028 |
| Registry record updated | July 24, 2026 |
| Trial ID | NCT07392801 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults and children starting long-term parenteral nutrition and treated at the participating French centers who can provide consent.
✕Probably not a fit
Patients who do not experience significant changes in AGE levels or who have factors that confound AGE measurements may see limited direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, observational study follows adults and children who begin long-term parenteral nutrition to see how their skin AGE levels change over 12 months. AGE levels will be measured non-invasively with the AGE Reader at baseline, 6 months, and 12 months, while nutrition bag AGE content is analyzed separately. Metabolic and nutritional data, including HbA1c, fructosamine, lipid profiles, and dietary records, will be collected at each time point. Samples from parenteral nutrition bags will be stored and analyzed after the final visit. The aim is to understand AGE kinetics from PN initiation and its potential link to metabolic and cardiovascular risks in this population.
Why it matters
Potential benefit: If successful, the study could clarify how long-term PN influences AGE accumulation, informing strategies to reduce related metabolic and cardiovascular risks.
How similar studies have gone: Previous data suggest a link between AGE accumulation and metabolic/cardiovascular complications, but prospective data from PN initiation are lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients (adults and children, all ages) initiating long-term parenteral nutrition * Followed at CHU de Bordeaux or Robert Debré Hospital (APHP) * Covered by French Social Security system * Written informed consent obtained from patient (if adult) or legal guardian (if minor) Exclusion Criteria: * Fitzpatrick skin type ≥ V (darker skin tones) * Forearm tattoos at the site of measurement * For patients included under 1 year of age: patients born prematurely (before 37 weeks of amenorrhea) * Pregnant or breastfeeding women.
Where it's running
-
CHU de Bordeaux - Hôpital Haut Lévêque
Pessac, France Recruiting -
CHU de Bordeaux-Hôpital des enfants GH Pellegrin
Bordeaux, France Not yet recruiting -
AP-HP - Hopital Robert Debré
Paris, France Not yet recruiting
Study contacts
- Principal investigator: Florian POULLENOT, MD — University Hospital, Bordeaux
- Study coordinator: Florian POULLENOT, MD
- Email: florian.poullenot@chu-bordeaux.fr
- Phone: +335 57 65 64 40
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.