Anabolic response to IV amino acids in people with chronic intestinal failure
Anabolic Response To Protein And Assessment Of Metabolic Phenotype In Patients With Home Parenteral Nutrition And Chronic Intestinal Failure
This will test whether giving IV amino acids helps people with chronic intestinal failure on home parenteral nutrition build and maintain body protein and better match their individual protein needs.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Institute of Oncology Ljubljana Academic / other |
| Locations | 1 site (Ljubljana) |
| Trial ID | NCT07422792 on ClinicalTrials.gov |
What this trial studies
This prospective cohort study gives intravenous amino acids to patients with chronic intestinal failure who are receiving home parenteral nutrition and measures their anabolic (protein-building) response. Researchers will measure protein kinetics and metabolic phenotype to estimate true protein requirements and inform personalization of parenteral nutrition mixtures. The protocol also includes analysis of short-chain fatty acid metabolism and gut microbiota function to explore links between microbial activity and host metabolism. Data aim to improve nutritional management and dosing precision for people with CIF.
Who should consider this trial
Good fit: Adults with chronic intestinal failure who are receiving home parenteral nutrition are the intended participants.
Not a fit: People who are not on home parenteral nutrition or who cannot undergo metabolic testing likely would not receive direct benefit from this protocol.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor parenteral nutrition protein content to individual needs, improving protein status and clinical management.
How similar studies have performed: Metabolic and amino acid infusion studies have shown useful protein-kinetic data in other groups, but applying detailed protein-kinetic measurements specifically to chronic intestinal failure patients on home parenteral nutrition is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.
Where this trial is running
Ljubljana
- Institute of Oncology Ljubljana — Ljubljana, Slovenia (Recruiting)
Study contacts
- Study coordinator: Klavdija Korošec
- Email: kkorosec@onko-i.si
- Phone: +386 31630065
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.