Anabolic response to IV amino acids in people with chronic intestinal failure
Official title: Anabolic Response To Protein And Assessment Of Metabolic Phenotype In Patients With Home Parenteral Nutrition And Chronic Intestinal Failure
Run by Institute of Oncology Ljubljana · NCT07422792 · Data updated 2026-11-12
This will test whether giving IV amino acids helps people with chronic intestinal failure on home parenteral nutrition build and maintain body protein and better match their individual protein needs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | Institute of Oncology Ljubljana Academic / other |
| Locations | 1 site (Ljubljana) |
| Status | Recruiting |
| Started | April 1, 2022 |
| Main results expected | March 31, 2024 |
| Study ends | December 31, 2027 |
| Registry record updated | February 20, 2026 |
| Trial ID | NCT07422792 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with chronic intestinal failure who are receiving home parenteral nutrition are the intended participants.
✕Probably not a fit
People who are not on home parenteral nutrition or who cannot undergo metabolic testing likely would not receive direct benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective cohort study gives intravenous amino acids to patients with chronic intestinal failure who are receiving home parenteral nutrition and measures their anabolic (protein-building) response. Researchers will measure protein kinetics and metabolic phenotype to estimate true protein requirements and inform personalization of parenteral nutrition mixtures. The protocol also includes analysis of short-chain fatty acid metabolism and gut microbiota function to explore links between microbial activity and host metabolism. Data aim to improve nutritional management and dosing precision for people with CIF.
Why it matters
Potential benefit: If successful, the findings could help clinicians tailor parenteral nutrition protein content to individual needs, improving protein status and clinical management.
How similar studies have gone: Metabolic and amino acid infusion studies have shown useful protein-kinetic data in other groups, but applying detailed protein-kinetic measurements specifically to chronic intestinal failure patients on home parenteral nutrition is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.
Where it's running
-
Institute of Oncology Ljubljana
Ljubljana, Slovenia Recruiting
Study contacts
- Study coordinator: Klavdija Korošec
- Email: kkorosec@onko-i.si
- Phone: +386 31630065
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.