Observing long-term changes in high myopia patients
Long Term Observation of Ocular Structure and Visual Function in Eyes With High Myopia：Wuhan High Myopia Study
This study is tracking changes in eye health and vision over four years in college students with high myopia to see if they can find clues to help manage the condition better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Sponsor | Renmin Hospital of Wuhan University Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT06162234 on ClinicalTrials.gov |
What this trial studies
This observational study aims to track the long-term changes in ocular structure and visual function in individuals with high myopia, defined as a refractive error of ≤-6.00D or an axial length greater than 26mm. The study will involve a cohort of 1000 participants, primarily college students, over a four-year period, utilizing advanced imaging technologies such as optical coherence tomography (OCT) to gather data on fundus structure and visual function. The goal is to identify biomarkers that may influence visual outcomes and provide insights for the prevention and management of high myopia.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 18 and older with high myopia, characterized by a spherical equivalent refraction of ≤-6.00D or an axial length of ≥26mm.
Not a fit: Patients with significant fundus diseases or those unable to cooperate with the examination may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved prevention and management strategies for high myopia, potentially reducing the incidence of visual impairment.
How similar studies have performed: While there have been studies focusing on myopia, this specific approach utilizing advanced imaging techniques in a large cohort is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Voluntarily sign informed consent; * Commit to follow the research procedures and cooperate with the whole process of the study; * Age ≥18 years old; * Best corrected visual acuity ≥0.1; * Spherical Equivalent Refraction≤-6.00D or axial length ≥26mm in high myopia group； Exclusion Criteria: * Unable or unwilling to sign informed consent; * Unable to cooperate with the examination; * Astigmatism ≤-1.5D； * Patients with refractive interstitial opacity so that fundus images cannot be collected； * Patients with fundus diseases such as diabetic retinopathy, hypertensive retinopathy, age-related macular degeneration, retinal vein obstruction, retinal artery obstruction, etc
Where this trial is running
Wuhan, Hubei
- Renmin Hospital of Wuhan University — Wuhan, Hubei, China (Recruiting)
Study contacts
- Study coordinator: QY Wu, MD
- Email: wuqyan@163.com
- Phone: +86 18672345926
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.