Observational study on young adults with ischemic stroke
Official title: Observational Dutch Young Symptomatic StrokE studY - Extended
Run by Radboud University Medical Center · NCT05853796 · Data updated 2026-11-12
This study looks at young adults aged 18-50 who have had a stroke to see what causes it and how to better treat and prevent strokes in this age group.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 50 Years |
| Sex | All |
| Enrollment | 280 (estimated) |
| Sponsor | Radboud University Medical Center Academic / other |
| Locations | 6 sites (Nijmegen, Gelderland and 5 other locations) |
| Status | Recruiting |
| Started | February 6, 2023 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2037 |
| Registry record updated | May 11, 2023 |
| Trial ID | NCT05853796 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are young adults aged 18-50 who have had a first-ever transient ischemic attack or acute ischemic stroke.
✕Probably not a fit
Patients with a history of previous strokes or hemorrhages, or those with contraindications for MRI, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on young adults aged 18-50 who have experienced a first-ever transient ischemic attack or acute ischemic stroke. It aims to understand the underlying causes and risk factors associated with ischemic strokes in this age group, which is often under-researched compared to older populations. By identifying modifiable risk factors and the role of hemostasis abnormalities, the study seeks to improve tailored antithrombotic therapy for these patients. The research will involve monitoring and analyzing patient data to enhance prevention strategies and treatment outcomes.
Why it matters
Potential benefit: If successful, this study could lead to more effective prevention and treatment strategies for young adults suffering from ischemic strokes.
How similar studies have gone: While there is limited research specifically targeting young adults with ischemic strokes, studies on stroke in older populations have shown success in identifying risk factors and improving treatment outcomes.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a first-ever transient ischemic attack (TIA) or acute ischemic stroke aged between 18 and 50 years old * For this study, acute stroke is defined as "occurence of acute neurological deficit lasting more than 24 hours, with confirmation on imaging (CT(-a) or MR(-a))".TIA is defined as "occurence of acute neurological deficit lasting less than 24 hours with confirmation of ischemia on MRI). * Patients have a kidney function eGFR\>30ml/min. Exclusion Criteria: * A history of clinical TIA, ischemic stroke or intracerebral hemorrhage * A intracerebral hemorrhage resulting from trauma, known aneurysm or underlying intracerebral malignancy. * A venous infarction, retinal infarction or amourosis fugax. * Inadequate control of the Dutch language to reliably sign an informed consent from and/or participate in the follow-up * Patients are excluded if they have a contra indication for 3T MRI.
Where it's running
-
Radboudumc
Nijmegen, Gelderland, Netherlands Recruiting -
Catharina Ziekenhuis
Eindhoven, North Brabant, Netherlands Not yet recruiting -
Medisch Spectrum Twente
Enschede, Overijssel, Netherlands Not yet recruiting -
Isala
Zwolle, Overijssel, Netherlands Not yet recruiting -
HagaZiekenhuis
The Hague, South Holland, Netherlands Not yet recruiting -
Medisch Centrum Leeuwarden
Leeuwarden, Netherlands Not yet recruiting
Study contacts
- Study coordinator: Frank-Erik De Leeuw, Prof.
- Email: frankerik.deleeuw@radboudumc.nl
- Phone: 0031650200314
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Best Care for Acute Stroke in General Wards
A nurse-led program called BEST CARE ICTUS_HC is tested in hospitals without Stroke Units to see if it reduces stroke complications and helps recovery after an acute ischemic or hemorrhagic stroke.
-
Hybrid mirror-primed rehabilitation for unilateral stroke
This trial will test whether adding enhanced mirror priming to conventional therapy helps adults who had a first-time one-sided stroke at least three months ago improve upper-arm movement.
-
Intra-arterial clot-dissolving treatment for medium-vessel ischemic stroke
The team will test whether giving tenecteplase directly into the artery helps adults with acute ischemic stroke caused by medium-vessel blockage or severe narrowing.
-
Dimephosphon® for recovery after acute ischemic stroke.
This trial will test whether Dimephosphon® given 24–72 hours after stroke onset helps adults with moderate acute ischemic stroke recover better than a placebo.
-
Endovascular treatment for stroke beyond 24 hours
This study is testing whether a specific stroke treatment can help people who have had a stroke more than 24 hours ago feel better and regain independence compared to just receiving standard care.
-
Heart assessment to check repeat-stroke risk in people with atrial fibrillation
This project will test whether detailed heart examinations can find which people with atrial fibrillation who just had an ischemic stroke are at high risk of having another stroke.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.