Observational study on young adults with ischemic stroke
Observational Dutch Young Symptomatic StrokE studY - Extended
This study looks at young adults aged 18-50 who have had a stroke to see what causes it and how to better treat and prevent strokes in this age group.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 280 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Radboud University Medical Center Academic / other |
| Locations | 6 sites (Nijmegen, Gelderland and 5 other locations) |
| Trial ID | NCT05853796 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on young adults aged 18-50 who have experienced a first-ever transient ischemic attack or acute ischemic stroke. It aims to understand the underlying causes and risk factors associated with ischemic strokes in this age group, which is often under-researched compared to older populations. By identifying modifiable risk factors and the role of hemostasis abnormalities, the study seeks to improve tailored antithrombotic therapy for these patients. The research will involve monitoring and analyzing patient data to enhance prevention strategies and treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are young adults aged 18-50 who have had a first-ever transient ischemic attack or acute ischemic stroke.
Not a fit: Patients with a history of previous strokes or hemorrhages, or those with contraindications for MRI, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective prevention and treatment strategies for young adults suffering from ischemic strokes.
How similar studies have performed: While there is limited research specifically targeting young adults with ischemic strokes, studies on stroke in older populations have shown success in identifying risk factors and improving treatment outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with a first-ever transient ischemic attack (TIA) or acute ischemic stroke aged between 18 and 50 years old * For this study, acute stroke is defined as "occurence of acute neurological deficit lasting more than 24 hours, with confirmation on imaging (CT(-a) or MR(-a))".TIA is defined as "occurence of acute neurological deficit lasting less than 24 hours with confirmation of ischemia on MRI). * Patients have a kidney function eGFR\>30ml/min. Exclusion Criteria: * A history of clinical TIA, ischemic stroke or intracerebral hemorrhage * A intracerebral hemorrhage resulting from trauma, known aneurysm or underlying intracerebral malignancy. * A venous infarction, retinal infarction or amourosis fugax. * Inadequate control of the Dutch language to reliably sign an informed consent from and/or participate in the follow-up * Patients are excluded if they have a contra indication for 3T MRI.
Where this trial is running
Nijmegen, Gelderland and 5 other locations
- Radboudumc — Nijmegen, Gelderland, Netherlands (Recruiting)
- Catharina Ziekenhuis — Eindhoven, North Brabant, Netherlands (Not_yet_recruiting)
- Medisch Spectrum Twente — Enschede, Overijssel, Netherlands (Not_yet_recruiting)
- Isala — Zwolle, Overijssel, Netherlands (Not_yet_recruiting)
- HagaZiekenhuis — The Hague, South Holland, Netherlands (Not_yet_recruiting)
- Medisch Centrum Leeuwarden — Leeuwarden, Netherlands (Not_yet_recruiting)
Study contacts
- Study coordinator: Frank-Erik De Leeuw, Prof.
- Email: frankerik.deleeuw@radboudumc.nl
- Phone: 0031650200314
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.