Observational study on Ventilator Associated Pneumonia in ICUs

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on Ventilator Associated Pneumonia (VAP), a serious bacterial infection affecting patients in Intensive Care Units (ICUs) who require mechanical ventilation. The study aims to establish and continuously train a network of ICUs to facilitate future clinical trials evaluating preventive and therapeutic options for VAP. By creating a structured network, the study seeks to improve the efficiency and quality of research in this area, ultimately preparing sites for randomized controlled trials. The initiative will also implement informed consent processes and maintain ongoing observational studies to gather valuable data.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Age≥18 years
* At risk of acquiring VAP during ICU stay, defined as:
* Requiring admission or being admitted to the ICU.
* Expected or documented to be under IMV for more than 48 hours.
* Consent, either a written informed consent given by the study patient in full medical, psychological, cognitive, social or legal capacity to give an informed consent, or, if not possible, by a Legally Authorized Representative of the study patient OR any applicable locally accepted form of consent OR consent waiver allowing data collection and sharing of data according to ECRAID's principles

Exclusion Criteria:

* Death is deemed to be imminent or inevitable during this hospital admission AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment.

Where it's running

• University Hospital of Trauma
  Tirana, Albania Recruiting
• Cliniques Universitaires Saint-Luc UCL
  Brussels, Belgium Recruiting
• Universitair Ziekenhuis Gent
  Ghent, Belgium Recruiting
• Hôpital de Jolimont
  La Louvière, Belgium Recruiting
• Clinical Hospital Center Rijeka
  Rijeka, Croatia Recruiting
• General Hospital "Dr. Josip Benčević" Slavonski Brod
  Slavonski Brod, Croatia Recruiting

Study contacts

• Study coordinator: Bruno FRANCOIS, MD
• Email: bruno.francois@chu-limoges.fr
• Phone: +33 05 55 05 69 83

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Probiotics to Prevent Pneumonia in Critically Ill Kids in the PICU

  We’re testing whether giving probiotics to critically ill children on a ventilator helps prevent ventilator-associated pneumonia.

  Recruiting Tanta University · Tanta, Al Gharbia · NCT07848165

• B Lymphocyte Populations in the Lungs of ICU Patients on Ventilation

  This study tests the presence and roles of B lymphocytes in the lungs of adults on invasive ventilation, to see how humoral immunity relates to ventilator-associated pneumonia.

  Recruiting University Hospital, Limoges · Limoges · NCT07436780

• Lactoferrin to help prevent infections in ventilated newborns

  This study tests whether giving lactoferrin to ventilated neonates can help prevent ventilator-associated pneumonia and related complications.

  Recruiting Tanta University · Tanta · NCT07255742

• Measuring breathing effort before and after removing the breathing tube

  This will test a new electrical impedance method to measure breathing effort in adults on ventilators as they try breathing on their own and after the breathing tube is removed.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07017608

• Rapid multiplex PCR on bronchoalveolar lavage to guide antibiotics for ventilator-associated pneumonia

  This trial tests whether using a fast multiplex PCR on bronchoalveolar lavage samples helps doctors choose the right antibiotics sooner for adults on mechanical ventilation suspected of ventilator-associated pneumonia.

  Recruiting CHU de Reims · Reims · NCT06554327

• Using acyclovir to treat pneumonia in ventilated patients with herpes simplex virus

  This study is testing if giving acyclovir to ICU patients on ventilators who have pneumonia and herpes simplex virus can help them survive better than those who don't receive the medication.

  Recruiting at 28 sites Phase 3 Jena University Hospital · Freiburg im Breisgau, Baden-Wurttemberg and 27 other locations · NCT06134492

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.