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Observational study on Ventilator Associated Pneumonia in ICUs

POS-VAP: Perpetual Observational Study - Ventilator Associated Pneumonia

Observational European Clinical Research Alliance for Infectious Diseases (ECRAID) · NCT05719259

This study is trying to set up a network of ICUs to help find better ways to prevent and treat Ventilator Associated Pneumonia in patients on mechanical ventilation.

Quick facts

Study typeObservational
Enrollment20000 (estimated)
Ages18 Years and up
SexAll
SponsorEuropean Clinical Research Alliance for Infectious Diseases (ECRAID) Academic / other
Locations35 sites (Tirana and 34 other locations)
Trial IDNCT05719259 on ClinicalTrials.gov

What this trial studies

This observational study focuses on Ventilator Associated Pneumonia (VAP), a serious bacterial infection affecting patients in Intensive Care Units (ICUs) who require mechanical ventilation. The study aims to establish and continuously train a network of ICUs to facilitate future clinical trials evaluating preventive and therapeutic options for VAP. By creating a structured network, the study seeks to improve the efficiency and quality of research in this area, ultimately preparing sites for randomized controlled trials. The initiative will also implement informed consent processes and maintain ongoing observational studies to gather valuable data.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 years and older who are at risk of acquiring VAP during their ICU stay and are expected to be on mechanical ventilation for more than 48 hours.

Not a fit: Patients who are imminently dying or for whom full active treatment is not being pursued will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved prevention and treatment strategies for Ventilator Associated Pneumonia, reducing morbidity and mortality in ICU patients.

How similar studies have performed: While this approach is novel in its focus on creating a dedicated network for VAP research, similar observational studies have shown promise in enhancing the execution of clinical trials in other areas.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion criteria:

* Age≥18 years
* At risk of acquiring VAP during ICU stay, defined as:
* Requiring admission or being admitted to the ICU.
* Expected or documented to be under IMV for more than 48 hours.
* Consent, either a written informed consent given by the study patient in full medical, psychological, cognitive, social or legal capacity to give an informed consent, or, if not possible, by a Legally Authorized Representative of the study patient OR any applicable locally accepted form of consent OR consent waiver allowing data collection and sharing of data according to ECRAID's principles

Exclusion Criteria:

* Death is deemed to be imminent or inevitable during this hospital admission AND one or more of the patient, substitute decision maker or attending physician are not committed to full active treatment.

Where this trial is running

Tirana and 34 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Ventilator Associated PneumoniaHospital Acquired InfectionMechanical VentilationIntensive Care Unit
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.