Rapid multiplex PCR on bronchoalveolar lavage to guide antibiotics for ventilator-associated pneumonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicenter, randomized controlled trial in eight university intensive care units in the Grand-Est region of France comparing multiplex PCR plus standard bacterial culture versus bacterial culture alone for suspected VAP. The multiplex test used is the BioFire FilmArray Pneumonia Panel Plus, performed on bronchoscopic bronchoalveolar lavage fluid and able to detect multiple bacterial DNA targets and resistance genes. Standard culture and susceptibility results typically take 48–72 hours, while the PCR gives much faster results that could inform empirical antibiotic choices. The primary comparison is the percentage of appropriate empirical antibiotic therapy in patients with culture-confirmed VAP.

Why it matters

Who can join: the full rules

inclusion criteria :

* Adult patients, hospitalized in intensive care unit
* on mechanical ventilation for at least 48 hours
* Suspected VAP
* With an indication for bronchoalveolar lavage (BAL)

exclusion criteria :

* Patients under legal protection or without social security coverage
* Pregnant women
* Previous episode of VAP during the same hospitalization

Where it's running

• Damien JOLLY
  Reims, France Recruiting

Study contacts

• Study coordinator: Antoine GOURY
• Email: agoury@chu-reims.fr
• Phone: 03 10 73 68 85

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.