Observational study on psoriasis and its risk for arthritis
Official title: Determining Risk Factors for the Development of Psoriatic Arthritis (PsA) Amongst People Living With Psoriasis: A Patient-driven On-line Prospective European Observational Cohort
Run by University of Oxford · NCT05858528 · Data updated 2026-11-12
This study is trying to find out which adults with psoriasis are more likely to develop psoriatic arthritis so that steps can be taken to prevent it.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 25000 (estimated) |
| Sponsor | University of Oxford Academic / other |
| Locations | 1 site (Oxford, Oxfordshire) |
| Status | Recruiting |
| Started | June 27, 2023 |
| Main results expected | June 30, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | April 2, 2025 |
| Trial ID | NCT05858528 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older with a self-reported diagnosis of skin psoriasis.
✕Probably not a fit
Patients who already have a pre-existing diagnosis of psoriatic arthritis will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The HIPPOCRATES Prospective Observational Study aims to identify patients with psoriasis who are at risk of developing psoriatic arthritis. Conducted across Europe, this study involves adults with psoriasis who will complete questionnaires every six months to monitor their condition. The research is led by the University of Oxford in collaboration with University College Dublin, focusing on understanding the progression from psoriasis to psoriatic arthritis. The ultimate goal is to prevent the onset of arthritis in at-risk individuals.
Why it matters
Potential benefit: If successful, this study could lead to early interventions that prevent the development of psoriatic arthritis in patients with psoriasis.
How similar studies have gone: Other studies have shown promise in identifying risk factors for psoriatic arthritis, making this approach both relevant and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult ≥18 years * Self-reported diagnosis of skin psoriasis (any form) * Participant is willing and able to give informed consent for participation in the study and complete data in one of the HPOS languages Exclusion Criteria: • Pre-existing diagnosis of PsA
Where it's running
-
Oxford University Hospital NHS Foundation Trust
Oxford, Oxfordshire, United Kingdom Recruiting
Study contacts
- Study coordinator: Laura C Coates, MBChB, PhD
- Email: laura.coates@ndorms.ox.ac.uk
- Phone: 01865737838
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
TRAF3IP2 gene variation (rs13190932) in people with psoriasis and psoriatic arthritis
This trial will test whether the TRAF3IP2 (rs13190932) gene variant changes how adults with psoriasis or psoriatic arthritis respond to methotrexate treatment.
-
Examining cytokine levels in psoriasis and psoriatic arthritis patients
This study is trying to see how certain proteins in the blood and skin of people with psoriasis and psoriatic arthritis can help us understand these conditions better.
-
Educational tool for melanoma patients with autoimmune diseases
This study is testing a new educational tool to help melanoma patients with autoimmune diseases understand their treatment options better and see how easy it is for them to use.
-
Understanding chronic inflammatory systemic diseases and their treatments
This study looks at patients with chronic inflammatory diseases to see how these conditions are related and how they can be treated better.
-
Using nivolumab to treat patients with autoimmune disorders and advanced cancer
This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.
-
Monitoring pregnancy outcomes for women exposed to Stelara and Tremfya
This study is tracking pregnancies in women who have used Stelara or Tremfya to see how these medications might affect the health and development of their babies.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.