Examining cytokine levels in psoriasis and psoriatic arthritis patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research aims to analyze the cytokine profiles of patients with psoriasis and psoriatic arthritis to enhance understanding of the diseases' pathophysiology and the role of cytokines in joint involvement. The study will compare cytokine levels in serum, after stimulation of peripheral blood mononuclear cells, and in skin biopsies. By investigating these profiles, the research seeks to clarify discrepancies in existing literature and provide insights into the inflammatory processes underlying these conditions.

Why it matters

Who can join: the full rules

Inclusion criteria:

* For psoriasis patients :

  * Age over 18 years old
  * Signed informed consent
  * 5 year old psoriasis at least
  * At least one skin lesion over 2 cm
  * Without any articular symptoms
  * Without any DMARDs
  * Without anticoagulant treatments or coagulation disease
  * With normal articular and enthesis sonography
* For psoriatic arthritis patients :

  * Age over 18 years old
  * Signed informed consent
  * Psoriatic arthritis according to CASPAR criteria
  * Without any DMARDs
  * Without anticoagulant treatments or coagulation disease
  * With at least one synovitis at inclusion
* For controls

  * Age and sex matched with a patient without any rheumatic or dermatologic medical conditions
  * No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old

Exclusion criteria:

▪ For psoriasis patients :

* Joint damage according to CASPAR criteria
* Echography activity in favor of chronic inflammatory rheumatism
* For patients and controls:
* Without social protection rights
* People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.

Where it's running

• Chu Poitiers
  Poitiers, France Recruiting

Study contacts

• Principal investigator: Guillaume LARID — Poitiers University Hospital
• Study coordinator: Guillaume LARID
• Email: rhumatologie@chu-poitiers.fr
• Phone: +33549444465

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.