Examining cytokine levels in psoriasis and psoriatic arthritis patients
Cytokine Expression in Sera, Ex Vivo Stimulated Peripheral Blood Mononuclear Cells Culture, and Skin in Psoriasis - Comparison of Patients with and Without Joint Involvement
This study is trying to see how certain proteins in the blood and skin of people with psoriasis and psoriatic arthritis can help us understand these conditions better.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | All |
| Sponsor | Poitiers University Hospital Academic / other |
| Locations | 1 site (Poitiers) |
| Trial ID | NCT05307809 on ClinicalTrials.gov |
What this trial studies
This research aims to analyze the cytokine profiles of patients with psoriasis and psoriatic arthritis to enhance understanding of the diseases' pathophysiology and the role of cytokines in joint involvement. The study will compare cytokine levels in serum, after stimulation of peripheral blood mononuclear cells, and in skin biopsies. By investigating these profiles, the research seeks to clarify discrepancies in existing literature and provide insights into the inflammatory processes underlying these conditions.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with a diagnosis of psoriasis or psoriatic arthritis who meet specific inclusion criteria.
Not a fit: Patients with joint damage or those currently on DMARDs or anticoagulant treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for psoriasis and psoriatic arthritis.
How similar studies have performed: While some studies have explored cytokine levels in these conditions, this research aims to provide a novel comparative analysis that has not been extensively conducted.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion criteria: * For psoriasis patients : * Age over 18 years old * Signed informed consent * 5 year old psoriasis at least * At least one skin lesion over 2 cm * Without any articular symptoms * Without any DMARDs * Without anticoagulant treatments or coagulation disease * With normal articular and enthesis sonography * For psoriatic arthritis patients : * Age over 18 years old * Signed informed consent * Psoriatic arthritis according to CASPAR criteria * Without any DMARDs * Without anticoagulant treatments or coagulation disease * With at least one synovitis at inclusion * For controls * Age and sex matched with a patient without any rheumatic or dermatologic medical conditions * No treatment with corticosteroïds or non-steroïdial anti-inflammatory drugsAge over 18 years old Exclusion criteria: ▪ For psoriasis patients : * Joint damage according to CASPAR criteria * Echography activity in favor of chronic inflammatory rheumatism * For patients and controls: * Without social protection rights * People under judiciary protection, of less than 18 years old, pregnant woman, breast feeding women, jailed patients.
Where this trial is running
Poitiers
- Chu Poitiers — Poitiers, France (Recruiting)
Study contacts
- Principal investigator: Guillaume LARID — Poitiers University Hospital
- Study coordinator: Guillaume LARID
- Email: rhumatologie@chu-poitiers.fr
- Phone: +33549444465
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.