Repeated exams to classify early pulmonary embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

RE-TyPE enrolls adults with pulmonary embolism at Sahlgrenska University Hospital and performs repeated biomarker sampling, electrocardiography, and point-of-care echocardiography during the initial 48 hours for intermediate-high risk patients, while also creating a broader registry for all PE patients with follow-up around day 90. The study compares dynamic changes across these repeated measures to conventional single-timepoint variables to see if trajectories better predict short- and medium-term clinical outcomes. Cohort A focuses on intensive early monitoring of intermediate-high risk patients enrolled within 48 hours, and Cohort B establishes a platform for longitudinal follow-up of all PE patients at the center. The program is designed both to improve early risk stratification and to build an ongoing infrastructure for quality improvement and long-term outcome tracking.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Adult patients (≥ 18 years old) who is diagnosed with, or followed as out-patients for, PE at Sahlgrenska University Hospital
2. Written informed consent

Exclusion Criteria from Cohort A:

1. Low risk, intermediate-low risk or high risk PE\*
2. \>48 hours since PE diagnosis
3. Expected inability to comply with the protocol (e.g. dementia)

Exclusion Criterium from Cohort B:

1\. Not geographically belonging to Sahlgrenska University Hospital

\*If biomarkers (and/or echocardiography) are not available in hemodynamically stable patients, RV/LV-ratio \>1 will be considered as preliminary intermediate-high risk. If biomarkers later fall out negative, the patient will be considered as intermediate-low risk and will be moved to Cohort B

Where it's running

• Sahlgrenska University Hospital/Sahlgrenska
  Gothenburg, Region Västra Götaland, Sweden Recruiting
• Sahlgrenska University Hospital/Mölndal
  Gothenburg, Region Västra Götaland, Sweden Not yet recruiting
• Sahlgrenska University Hospital/Östra
  Gothenburg, Region Västra Götaland, Sweden Not yet recruiting

Study contacts

• Study coordinator: Rickard Zeijlon, MD, PhD
• Email: rickard.zeijlon@vgregion.se
• Phone: +46313428884

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.