Best time for reperfusion in acute pulmonary embolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a national, multicenter, prospective observational study enrolling adults with imaging‑confirmed high‑risk or intermediate‑high‑risk pulmonary embolism at participating Italian centers. Investigators will record timing from symptom onset and hospital admission to reperfusion with systemic thrombolysis or catheter‑directed therapies and track in‑hospital mortality as well as hemorrhagic and cardiovascular complications. Time‑to‑treatment analyses will be used to identify temporal cutoffs associated with better outcomes while accounting for comorbidities and bleeding risk. The goal is to provide evidence on whether a specific reperfusion time window is associated with improved short‑term clinical outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Patients with a diagnosis of intermediate-high or high pulmonary embolism confirmed by computed tomography pulmonary angiography (CTPA), pulmonary angiography, or echocardiography (evidence of a floating thrombus in the right atrium or right ventricle, or proximal visualization of thrombus in the pulmonary artery).
* Classified as high-risk or intermediate-high-risk according to the 2019 European Society of Cardiology guidelines.
* Provision of informed consent for the processing of personal data.

Exclusion Criteria:

* Age \< 18 years
* Patients in whom a diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism has been excluded.
* Inability to provide informed consent.

Where it's running

• UO Unità di Cure Intensive Cardiologiche e Cardiologia 1, Ospedale Niguarda, Milano
  Milan, Milano, Italy Recruiting
• UOC di Cardiologia, Ospedali Riuniti Padova Sud, Monselice, Italia
  Monselice, Padova, Italy Recruiting
• IRCCS Policlinico San Matteo
  Pavia, Pavia, Italy Recruiting
• UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia
  Perugia, Perugia, Italy Recruiting
• UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia
  Pisa, Pisa, Italy Recruiting
• UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino
  Torino, Torino, Italy Recruiting

Study contacts

• Principal investigator: Claudio Bilato, MD PhD — Department of Cardiology, Azienda AULSS 8 Berica, Arzignano (Vicenza), Italy
• Study coordinator: Claudio Bilato, MD PhD
• Email: claudio.bilato@aulss8.veneto.it
• Phone: +390444479106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.