New method for diagnosing severe corneal infections
Official title: Use of a New Rapid Multiplex PCR System for the Microbiological Diagnosis of Severe Infectious Keratitis: Impact on Therapeutic Management (ABCORFILM Study)
Run by CHU de Reims · NCT05888987 · Data updated 2026-11-12
This study is testing a new fast testing method for severe eye infections to see if it can quickly identify the cause better than standard tests, helping patients get the right treatment sooner.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | CHU de Reims Academic / other |
| Locations | 1 site (Reims) |
| Status | Recruiting |
| Started | July 7, 2023 |
| Main results expected | January 7, 2027 |
| Study ends | August 7, 2027 |
| Registry record updated | September 19, 2024 |
| Trial ID | NCT05888987 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 years old who are hospitalized for severe infectious keratitis.
✕Probably not a fit
Patients who have received any local or systemic antibiotic treatment within 48 hours prior to corneal sampling may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a new PCR-based diagnostic method for severe infectious keratitis, a condition that can lead to blindness and requires immediate hospitalization. It involves two groups of patients: one group receiving standard diagnostic methods and another group undergoing rapid multiplex PCR testing using FilmArray systems. The goal is to compare the effectiveness of this new approach against conventional methods in identifying pathogens quickly, thereby facilitating timely treatment.
Why it matters
Potential benefit: If successful, this method could significantly reduce the time to diagnosis and improve treatment outcomes for patients with severe corneal infections.
How similar studies have gone: Other studies using rapid multiplex PCR for infectious diseases have shown promising results, suggesting potential success for this novel application in ophthalmology.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: * Over 18 years old * With social security affiliation * Willing to participate this study * Hospitalized in our department for severe infectious keratitis Non-inclusion criteria: * Any prior (48 hours) or concomitant treatment with local or systemic antibiotherapy at time of corneal scrapping and swabbing * Patient not covered by the French Health Insurance * Unable to give informed consent
Where it's running
-
Damien JOLLY
Reims, France Recruiting
Study contacts
- Study coordinator: Alexandre DENOYER
- Email: adenoyer@chu-reims.fr
- Phone: 03 26 78 78 88
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Non-invasive diagnostics for eye infections
This study is testing new ways to quickly and accurately diagnose different types of eye infections to help people avoid vision loss and get better treatment.
-
Does the order of endurance and strength training in COPD rehab matter for muscle strength?
This study tests whether doing strength training before endurance training during pulmonary rehab improves muscle strength in adults with COPD.
-
Right ventricular–arterial coupling during fluid loading in ICU patients
This study tests how the right ventricle handles fluid changes in critically ill adults to see how it affects blood flow and congestion.
-
Social cognition in severe alcohol use disorder
This study tests how social-cognition abilities relate to brain structure in adults with severe alcohol use disorder who are abstinent and receiving care.
-
PALMIRE cohort: phenotyping inflammatory lung diseases to enable personalized care
This project will collect clinical, imaging, and biological data from adults with asthma, COPD, bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, or interstitial lung disease to try to identify disease subtypes and markers that could guide more personalized care.
-
Antiphospholipid syndrome in people 65 and older who had an ischemic stroke
This study will test whether routine blood testing for antiphospholipid antibodies in people aged 65 and over hospitalized with ischemic stroke or TIA can identify previously unrecognized antiphospholipid syndrome.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.