Neuromodulation for relieving phantom limb pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of various neuromodulation techniques, including Motor Cortex Stimulation, Spinal Cord Stimulation, Peripheral Nerve Stimulation, and Dorsal Root Ganglion Stimulation, in alleviating phantom limb pain in patients who have undergone limb amputation. Participants will have electrodes implanted to stimulate peripheral nerves and other targeted areas to assess pain relief. The study focuses on individuals experiencing chronic pain at least six months post-amputation, aiming to provide a novel approach to managing this debilitating condition.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Amputation of the upper limb at the level of the forearm or upper arm, or amputation of the lower limb at the level of the lower leg or thigh.
* Age between 18 and 65 years.
* Duration since amputation is at least 6 months.
* Presence of persistent chronic pain syndrome rated between 4 and 10 on the Visual Analog Scale (VAS).
* Absence of pregnancy at the time of implantation, confirmed by a pregnancy test (for female participants only).
* Signed consent to participate in the study.

Exclusion Criteria:

* Presence of severe somatic pathology that hinders surgical treatment and participation in the study.
* Presence of psychiatric disorders (including a history of), severe depression, suicidal tendencies, or a history of suicide attempts.
* Presence of severe orthopedic deformity in the limb above the level of amputation.
* History of cancer.
* History of epilepsy.
* Complicated traumatic brain injury (TBI) or a history of stroke.
* Inability to undergo electrostimulation due to other somatic pathology.
* Purulent-septic pathology.
* Drug addiction (including a history of).
* Congenital anomaly of upper limb development.
* Anomalies in the development of the central and peripheral nervous systems.

Where it's running

• Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia
  Moscow, Moscow, Russia Recruiting
• Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia
  Moscow, Russia Recruiting

Study contacts

• Study coordinator: Yury Matveenko
• Email: medtream@gmail.com
• Phone: +79163843070

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Neuropathic pain after childhood amputation

  This project sees how common phantom and residual limb neuropathic pain is and how it affects children and teens who had limb amputations.

  Recruiting Hopitaux de Saint-Maurice · Saint-Maurice · NCT07401966

• Effects of magnetic stimulation on phantom limb pain in amputees

  This study tests if using magnetic stimulation can help reduce phantom limb pain in people who have had upper limb amputations.

  Recruiting Skolkovo Institute of Science and Technology · Moscow · NCT06813937

• Preventing pain after lower limb amputation using targeted muscle reinnervation

  This study is testing if a new technique called Targeted Muscle Reinnervation can help reduce pain after lower limb amputation compared to standard nerve handling.

  Recruiting Leiden University Medical Center · Amsterdam, North Holland and 6 other locations · NCT06719245

• Evaluating a neuroprosthesis to reduce phantom limb pain and improve quality of life

  This study is testing a new device to see if it can help people with phantom limb pain feel better and improve their experience with bionic limbs.

  Recruiting at 2 sites Skolkovo Institute of Science and Technology · Moscow and 1 other locations · NCT06702904

• Treatment for phantom limb pain using visual simulation therapy

  This study is testing if a new therapy using visual simulations can help amputees with phantom limb pain feel less discomfort compared to standard care.

  Recruiting Oslo Metropolitan University · Oslo · NCT06483035

• Reducing phantom limb pain in amputees

  This study is testing two different rehabilitation programs to see which one helps amputees with phantom limb pain feel better.

  Recruiting Neuroscience Research Australia · Randwick, New South Wales · NCT06167330

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.