Collection of blood and brain tissue samples from patients with drug-resistant epilepsy
Multimodal Study of the Human Brain Epilepsy Tissue
This study is collecting blood and brain tissue samples from adults with drug-resistant epilepsy who are having surgery to help researchers find new ways to understand and treat the condition.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT06022055 on ClinicalTrials.gov |
What this trial studies
This study focuses on collecting blood and brain tissue samples from adult patients with focal drug-resistant epilepsy who are undergoing surgery. The goal is to create an annotated biorepository to support research aimed at identifying new pathophysiological biomarkers associated with the condition. Investigators will employ a multimodal approach, including electrophysiological analyses, immunohistochemistry, genetic studies, and biochemical analyses. Samples will be stored for future research, and patients will be followed up for clinical evaluations within 36 months post-surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with focal drug-resistant epilepsy who are hospitalized for pre-surgical evaluation or surgery.
Not a fit: Patients who do not have focal drug-resistant epilepsy or are under 18 years old may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to the identification of new biomarkers that improve the understanding and treatment of drug-resistant epilepsy.
How similar studies have performed: While similar studies have explored biomarkers in epilepsy, this multimodal approach to creating a biorepository is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 yo or above * patients with a focal drug-resistant epilepsy * patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery * consent obtained from the patient, or legally authorized representative * affiliated to a social security system Exclusion Criteria: * None
Where this trial is running
Paris
- Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière Hospital — Paris, France (Recruiting)
Study contacts
- Principal investigator: Vincent M. Navarro, MD, PHD — Aphp
- Study coordinator: Vincent M. Navarro, MD, PHD
- Email: Vincent.navarro@aphp.fr
- Phone: 01 42 16 19 40
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.