Collection of blood and brain tissue samples from patients with drug-resistant epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on collecting blood and brain tissue samples from adult patients with focal drug-resistant epilepsy who are undergoing surgery. The goal is to create an annotated biorepository to support research aimed at identifying new pathophysiological biomarkers associated with the condition. Investigators will employ a multimodal approach, including electrophysiological analyses, immunohistochemistry, genetic studies, and biochemical analyses. Samples will be stored for future research, and patients will be followed up for clinical evaluations within 36 months post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 yo or above
* patients with a focal drug-resistant epilepsy
* patients hospitalized for a pre-surgical evaluation or for an epilepsy surgery
* consent obtained from the patient, or legally authorized representative
* affiliated to a social security system

Exclusion Criteria:

* None

Where it's running

• Department of Neurology, Epilepsy Unit, Pitié-Salpêtrière Hospital
  Paris, France Recruiting

Study contacts

• Principal investigator: Vincent M. Navarro, MD, PHD — Aphp
• Study coordinator: Vincent M. Navarro, MD, PHD
• Email: Vincent.navarro@aphp.fr
• Phone: 01 42 16 19 40

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Temporal Interference Brain Stimulation for adults with drug-resistant focal epilepsy during stereo-EEG monitoring

  This study tests whether a non-invasive Temporal Interference brain stimulation can reduce abnormal brain activity in adults with drug-resistant focal epilepsy who are undergoing stereo-EEG monitoring.

  Recruiting Duke University · Durham, North Carolina · NCT07764718

• Impact of the brain’s adenosine pathway on epilepsy and arousal in adults

  This study tests how the brain’s adenosine system affects arousal and breathing in adults with drug-resistant focal epilepsy compared with healthy volunteers.

  Recruiting Hospices Civils de Lyon · Bron · NCT07249034

• Nervous system study: sleep, seizures, and dreams in epilepsy with brain stimulation

  This study tests whether direct brain stimulation during sleep can influence nocturnal seizures and interictal discharges in adults with drug-resistant focal epilepsy undergoing SEEG.

  Recruiting Hospices Civils de Lyon · Durham, North Carolina and 1 other locations · NCT07605858

• Genetic and electrophysiologic analysis in children with drug-resistant epilepsy

  This study is testing if certain genetic changes in the brain are linked to drug-resistant epilepsy in children to help us understand why these conditions happen.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT02890641

• Modified ketogenic diet for adults with drug-resistant epilepsy

  This study tests whether a modified ketogenic diet can help adults with drug-resistant epilepsy see fewer seizures and feel better overall.

  Recruiting Karolinska Institutet · Stockholm · NCT07878104

• Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

  This study tests whether low intensity focused ultrasound can help reduce seizures in adults with drug‑resistant epilepsy.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07680842

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.