OPM-MEG Brain Imaging in Young People with Immune- and Non-immune Related Neurological Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study uses an advanced, wearable MEG technology (OPM-MEG) alongside standard MEG, MRI, and neuropsychology testing to characterize brain function in children and adolescents aged 2 to 16 with immune- and non-immune–mediated neurological diseases. It is a longitudinal cross-sectional cohort study conducted at the Aston Institute of Health and Neurodevelopment, with recruitment from Birmingham, London, and Manchester. Participants will undergo up to three study visits over five years, including neuroimaging and cognitive assessments; visits may be split and travel accommodations provided. The aim is to understand brain network changes, compare immune- and non-immune etiologies, and explore potential markers for prognosis and disease monitoring.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals (age range 2 yrs to 16 years) who have received a diagnosis of immune-mediated neurological disease e.g. autoimmune encephalitis1, acute disseminated encephalomyelitis, multiple sclerosis. 2
* Individuals who have received a diagnosis of a non-immune mediated neurological disease (age range 2 yrs to 15 years 11 months) e.g. stroke.
* Patients who can give informed consent/ assent and have a person with parental responsibility capable of giving informed consent on their behalf if aged \<16 years.

Exclusion Criteria:

* There is metal in the body or any other contraindication that precludes MRI scanning at IHN, or child usually requires sedation for clinical MRI scans.
* Participant dissents.

Where it's running

• Birmingham Children's Hospital
  Birmingham, West Midlands, United Kingdom Recruiting
• Aston University
  Birmingham, United Kingdom Recruiting

Study contacts

• Principal investigator: Sukhvir Wright — Aston University
• Study coordinator: Sukhvir Wright, MBBS, DPhil
• Email: omegamind@aston.ac.uk
• Phone: +44 121 204 3076

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.