Monitoring movement in adults with spinal muscular atrophy using wearable sensors
Official title: Decentralised Monitoring of Motor Function in Adolescents Aged 15 and Older and Adults With Spinal Muscular Atrophy (2026-184)
Run by Centre Hospitalier Universitaire de Liege · NCT07894185 · Data updated 2026-11-12
This study tests whether wearable devices can continuously track how SMA affects daily movement in adults and teens 15 years and older.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 15 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Liege Academic / other |
| Locations | 1 site (Liège) |
| Status | Recruiting |
| Started | July 17, 2026 |
| Main results expected | March 28, 2028 |
| Study ends | March 2029 |
| Registry record updated | October 26, 2026 |
| Trial ID | NCT07894185 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Candidates are individuals aged 15 years or older with genetically confirmed SMA on stable disease-modifying therapy for at least one year.
✕Probably not a fit
Participants may not experience direct health benefits from the study, and results may not influence their individual care.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This academic, single-center study will follow about 60 participants aged 15 and up with SMA over 36 months, using wearable sensors to collect real-world motor data. It is fully decentralized, with a 24-month enrollment period and 12–30 months of follow-up, to quantify motor impairments across SMA forms. The goal is to develop a validated digital measure of motor function in adults with SMA, complementing hospital-based assessments. Participation involves ongoing sensor wear and does not promise direct clinical benefit. The study analyzes gait and overall activity using the Syde device to capture daily fluctuations in motor performance.
Why it matters
Potential benefit: If successful, the digital measures could improve monitoring of SMA progression and response to therapy in real life settings.
How similar studies have gone: Wearable-based monitoring has shown promise in other neuromuscular conditions, but validated digital outcomes for adults with SMA are not yet established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with genetically confirmed spinal muscular atrophy and available SMN2 copy number or if unavailable, they will be offered the option to send a DBS (dried blood spot) for SMN2 copy evaluation. * On stable Disease modifying treatment for at least one year. * The participant must be willing and able to provide written informed consent for study participation. * Aged 15 years or older. Exclusion Criteria: * Any acute or chronic condition that, in the investigator's opinion, significantly interferes with assessments and/or motor development. * Participation in a therapeutic trial with unapproved treatment. * absence of internet connection.
Where it's running
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Centre de référence des maladies neuromusculaires, Centre Hospitalier Régional de la Citadelle
Liège, Belgium Recruiting
Study contacts
- Study coordinator: Tamara Dangouloff, PhD
- Email: tamara.dangouloff@uliege.be
- Phone: +33662438138
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.