One-Step No-Prep approach to restore worn teeth and jaw function
Official title: Investigation of the Orthodontic and Articular Effects of the One-Step No-Prep Protocol
Run by Centre Hospitalier Universitaire de Liege · NCT07533240 · Data updated 2026-11-12
This study tests whether combining no-prep bonded restorations with simple orthodontic tooth movement helps adults with localized tooth wear regain a stable, comfortable bite and normal jaw function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Liege Academic / other |
| Locations | 1 site (Liège) |
| Status | Recruiting |
| Started | April 2026 |
| Main results expected | February 24, 2041 |
| Study ends | February 24, 2041 |
| Registry record updated | April 16, 2026 |
| Trial ID | NCT07533240 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with localized tooth wear who are being treated (or have been treated) using the One-Step No-Prep protocol and who can read French and consent to the assessments are ideal candidates.
✕Probably not a fit
Patients with extensive generalized tooth wear requiring full preparation, complex orthodontic or surgical reconstruction, or who cannot complete French-language assessments or attend the Liège center are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial follows adults treated with the One-Step No-Prep protocol, which pairs minimally invasive bonded restorations with controlled orthodontic extrusion to re-establish posterior occlusion. Both prospective and retrospective patients are included, with prospective cases undergoing standardized digital records including intraoral scans, low-dose cone-beam CT, and 3D jaw-tracking. Outcomes measured are the magnitude and predictability of tooth movements, time to regain full occlusion, changes in facial vertical height, TMJ position and function, and the clinical performance of PICN restorations. Patient comfort, function, esthetics, and satisfaction are collected through questionnaires with follow-up to 5 years and an additional 10-year evaluation where available.
Why it matters
Potential benefit: If successful, the approach could offer a predictable, minimally invasive way to restore worn teeth while improving bite stability and jaw comfort long-term.
How similar studies have gone: Early clinical reports and case series have shown promising results with no-prep bonded restorations and controlled extrusion, but comprehensive, long-term, systematically collected data are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Localized tooth wear that will be treated, or has already been treated, using the OSNPO protocol. * Age 18 years or older. * Sufficient cognitive ability to understand the study procedures and complete the required assessments. * Ability to read and complete the study questionnaires in French. * Written informed consent provided. Exclusion Criteria: * No exclusion criteria.
Where it's running
-
University Hospital of Liège
Liège, Belgium Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.