Testing fatigue levels in patients with spinal muscular atrophy
Official title: Evaluation of the Reproducibility of a Fatigability Test Fitted to Patients With Spinal Muscular Atrophy
Run by Centre Hospitalier Universitaire de Saint Etienne · NCT06562283 · Data updated 2026-11-12
This study is testing new ways to measure fatigue in people with spinal muscular atrophy to help them manage their daily activities better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 4 sites (Saint-Etienne, France and 3 other locations) |
| Status | Recruiting |
| Started | December 6, 2024 |
| Main results expected | October 2026 |
| Study ends | October 2026 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT06562283 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients aged 6 years and older with genetically confirmed spinal muscular atrophy.
✕Probably not a fit
Patients with other significant neurological diseases or joint deformities that interfere with testing may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates a fatigability test specifically designed for patients with spinal muscular atrophy (SMA), a neuromuscular disease characterized by motor neuron degeneration. The research aims to adapt and validate a series of tests, including thumb and grip tests, as well as a quadriceps intermittent fatigue test, to assess muscle fatigue in SMA patients. By understanding fatigue levels, the study seeks to improve the management of daily activities for those affected by SMA, particularly in patients who have received treatment aimed at restoring SMN protein expression. The study includes patients aged 6 years and older who have a confirmed diagnosis of SMA.
Why it matters
Potential benefit: If successful, this study could lead to better assessment and management of fatigue in patients with spinal muscular atrophy, enhancing their quality of life.
How similar studies have gone: While this approach is tailored for SMA, similar fatigue assessments have shown promise in other neuromuscular conditions, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Genetically confirmed spinal muscular atrophy * Age ≥ 6 years * No orthopaedic surgery in the 6 months prior to inclusion * Informed consent signed by the patient(s) or parent(s)/legal guardian(s) and assent of the patient * Affiliated or beneficiary of a health insurance scheme (for inclusion in France) Exclusion Criteria: * Other condition that may significantly interfere with the assessment of the SMA and which is clearly unrelated to the disease * Other associated neurological disease * Joint deformities that prevent correct and comfortable positioning with the various different measuring devices (thumb-index clamp, handgrip and QIF-test) * Contraindication to transcranial magnetic stimulation
Where it's running
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Unités de Myologie et de Médecine du Sport
Saint-Etienne, France, France Recruiting -
HCL - Hôpital Croix Rousse
Lyon, France Recruiting -
HFME - Hospices Civils de Lyon
Lyon, France Recruiting -
Aphp - Hopital Pitie Salpetriere
Paris, France Recruiting
Study contacts
- Principal investigator: Leonard FEASSON, MD PhD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Leonard FEASSON, MD PhD
- Email: leonard.feasson@chu-saint-etienne.fr
- Phone: (0)4 77 12 03 83
Similar studies
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-
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.