Mobile-based home cardiac rehab to see if it reduces non-calcified coronary plaque

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized controlled trial enrolling 176 adults with mild-to-moderate coronary stenosis. Participants are randomized to a personalized lifestyle program delivered via a mobile platform or to routine clinical care. The primary outcome is the change in non-calcified coronary plaque volume measured by CTA at 12 months, with follow-up to 36 months to assess long-term effects on plaque progression and cardiovascular outcomes. The study evaluates a digital, home-based rehabilitation approach in improving vascular health for CAD patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1.Diagnosis of mild-to-moderate coronary artery stenosis: presence of plaque in any coronary artery causing mild (\<50%) or moderate (50%-69%) luminal stenosis.

  2.Age between 18 and 70 years. 3.Asymptomatic during exercise or recovery phases of cardiopulmonary assessment, including absence of angina, ST-segment depression, or complex arrhythmias at rest or during exercise.

  4.Normal troponin levels. 5.Provided signed informed consent.

Exclusion Criteria:

* 1\. Severe coronary artery stenosis. 2.Presence of severe respiratory or cardiovascular diseases (e.g., acute myocardial infarction, acute tachyarrhythmia, pulmonary edema, severe aortic stenosis).

  3.Angina symptoms or signs during low-intensity exercise (\<5 METs) or recovery. 4.Complex arrhythmias at rest or during exercise. 5.Hemodynamic abnormalities during exercise (e.g., failure of systolic blood pressure or heart rate to increase, or a decrease in blood pressure with increased exercise workload).

  6.Severe psychological disorders. 7.Left ventricular ejection fraction (LVEF) \< 40%. 8.Elevated troponin levels. 9.Inability to undergo cardiopulmonary exercise testing due to neuromuscular or musculoskeletal disorders.

  10.Presence of other severe comorbidities. 11.Refusal to sign informed consent.

Where it's running

• Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
  Beijing, China Recruiting

Study contacts

• Study coordinator: Xue Feng
• Email: 29611290@qq.com
• Phone: +86-10-8839-6216

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• TAVI and PCI vs SAVR and CABG in low- and intermediate-risk patients with severe aortic stenosis and CAD

  This observational study compares TAVI plus PCI to SAVR plus CABG for patients who have both severe aortic stenosis and coronary artery disease.

  Recruiting Alexandria University · Alexandria, Alexandira · NCT07926022

• Resveratrol and Estrogen Receptors in Postmenopausal Women with CAD

  This study tests whether taking resveratrol is safe and can change estrogen-related markers in postmenopausal women with coronary artery disease.

  Recruiting InCor Heart Institute · São Paulo, São Paulo · NCT07865377

• Predicting Plaque Growth Using Blood Flow Stress Markers

  This study tests whether combining blood flow patterns in the heart arteries with how blood-flow–sensitive cells respond can help predict which plaques will grow in people with coronary artery disease.

  Recruiting Queen Mary University of London · London · NCT07864051

• Identifying Coronary Plaque Traits with Photon-counting CT and Multimodality Imaging

  This study tests whether advanced imaging can better identify risky artery plaques in people with stable angina.

  Recruiting Queen Mary University of London · London · NCT07864025

• PCI Registry at University Hospital Basel for Complex Coronary Procedures

  This registry collects real-world data from adults undergoing percutaneous coronary interventions at University Hospital Basel to see how different treatments like drug-eluting stents, drug-coated balloons, and bioresorbable scaffolds perform in diverse patients.

  Recruiting University Hospital, Basel, Switzerland · Basel, Canton of Basel-City · NCT07814157

• Health for Hungary: Long-term blood and health data collection to study aging and disease onset

  This study tests whether routine blood tests plus advanced molecular analyses can help detect the early stages of non-communicable diseases in adults over 40.

  Recruiting at 21 sites Center for Molecular Fingerprinting Research Nonprofit LLC · Balatonfüred and 32 other locations · NCT07743021

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.