Predicting Plaque Growth Using Blood Flow Stress Markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In coronary artery disease, some plaques grow and may rupture, causing a heart attack. This study combines coronary imaging to map blood flow patterns with blood-derived endothelial cells to see how cells respond to flow stress, aiming to better predict plaque progression. Participants will undergo a specialized CT coronary angiography scan and provide a blood sample for endothelial cell analysis; their plaques will be tracked over time. The approach uses computational fluid dynamics to assess wall shear stress alongside biological responses to improve prediction of plaque growth. The study is exploratory and focuses on identifying patient-specific factors that influence plaque progression.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥40
2. Stable angina, defined as typical symptoms with evidence of reversible ischemia in non-invasive test and/or documented obstructive coronary artery disease on coronary angiography (\>70% stenosis of at least one major epicardial coronary artery or positive fractional flow reserve study)
3. Patient that is willing and can provide written informed consent.

Exclusion Criteria:

1. Acute coronary syndrome within \<3 months
2. Estimated glomerular filtration rate (eGFR) \<60ml/min/1.73m²
3. Previous coronary artery bypass surgery
4. Decompensated heart failure, or left ventricular ejection fraction ≤30%
5. Patient allergic to contrast or cannot receive treatment with aspirin, heparin, or thienopyridines
6. Anticipated life expectancy \<2 years
7. Flow limiting coronary artery disease in the proximal segments of all the 3 epicardial coronaries
8. History of heart transplantation
9. Patient that requires surgical revascularization
10. Extensive coronary artery disease (i.e., multiple chronic total occlusions) or tortuous coronary anatomy that does not allow assessment of the coronary arteries with intravascular imaging
11. Pregnant women will be excluded. All women of childbearing potential will undergo a pregnancy risk assessment and a urine pregnancy test prior to the 12-month PCCTA scan, in line with standard clinical practice for all PCCTA scans.

Where it's running

• Queen Marys University London
  London, United Kingdom Recruiting

Study contacts

• Study coordinator: Paul C Evans
• Email: paul.evans@qmul.ac.uk
• Phone: +447825611695

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.