Identifying Coronary Plaque Traits with Photon-counting CT and Multimodality Imaging

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses photon-counting CT together with intravascular imaging and other modalities to characterize coronary plaques in patients with stable angina or related ischemic heart disease. Eligible adults aged 18 to 79 who recently had a CT angiogram showing a lesion requiring further evaluation may undergo detailed plaque assessment to see how imaging features relate to risk. The goal is to improve understanding of which plaques are vulnerable and how noninvasive and invasive imaging can be combined to guide treatment. The study compares multimodality imaging findings with standard assessments to inform future patient management. No intervention beyond imaging and data collection is performed as part of the study.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Able and willing to give informed consent
* Between ages 18-79
* Patients with a stable coronary syndrome that had recent PC-CTA showing at least one lesion requiring further evaluation with intravascular imaging or fractional flow reserve and is considered suitable for PCI under IVUS guidance

Exclusion Criteria:

* Unable to or unwilling to give informed consent
* Age \>80 years
* Recent acute coronary syndrome within \< 3 months
* Renal failure (eGFR \<60ml/min/1.73m²)
* History of previous coronary artery bypass surgery
* Decompensated heart failure, or left ventricular ejection fraction ≤30%
* Previous heart transplantation
* Intravenous contrast allergy
* Unable to receive treatment with aspirin, heparin, or thienopyridines
* Anticipated life expectancy \<1 year
* Pregnancy
* Patient that requires surgical revascularisation
* Extensive coronary artery disease (i.e. multiple chronic total occlusions) or tortuous coronary anatomy that does not allow assessment of the coronary arteries with NIRS-IVUS imaging

Where it's running

• William Harvey Research Institute, Barts and The London, Queen Mary University of London
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Christos V Bourantas, MD PhD — Barts Health NHS Trust and Queen Mary University of London
• Study coordinator: Ameer Hamid A Khan, MBBS BSc MSc
• Email: a.h.a.khan@qmul.ac.uk
• Phone: 447780356028

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.