Clinical trial Recruiting at 1 site Interventional Ages 40 to 55 Men only

Isometric Handgrip Training Before and After Heart Surgery to Boost Recovery

Official title: Impact of Pre- and Early Post-operative Isometric Handgrip Training on Functional Capacity and Autonomic Function After Sternotomy

Run by Cairo University · NCT07906873 · Data updated 2026-11-12

This study tests whether gentle handgrip exercise before and after open-heart surgery helps people recover their physical ability and autonomic function.

Quick facts

Study typeInterventional
Ages40 Years to 55 Years
SexMen only
Enrollment50 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Giza)
StatusRecruiting
StartedOctober 16, 2026
Main results expectedFebruary 2027
Study endsFebruary 2027
Registry record updatedNovember 2, 2026
Trial IDNCT07906873 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Male patients aged 40-55 with ejection fraction >40% undergoing elective open-heart surgery via median sternotomy, capable of following exercise instructions, and medically stable postoperatively.

Probably not a fit

Patients with sternal infection, unstable postoperative condition, musculoskeletal or cognitive impairments limiting exercise, anemia, uncontrolled hypertension, or arrhythmias may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study examines the effect of isometric handgrip training, using a hand dynamometer, administered before and after sternotomy in adults undergoing elective open-heart surgery. Participants perform 30% maximal effort handgrip contractions for 2 minutes per hand with 1-minute rest, totaling 20 minutes daily, starting 2 days before surgery and resuming after stabilization postoperatively. Outcomes include functional capacity measures (6-minute walk test), autonomic function (heart rate recovery), hemodynamics, rate pressure product, handgrip strength, and anxiety levels. Standard care such as breathing and mobilization exercises continues alongside the training. The goal is to determine if this low-cost, safe intervention can enhance early cardiac rehabilitation and reduce postoperative complications.

Why it matters

Potential benefit: If successful, patients may experience faster functional recovery and improved autonomic function after sternotomy.

How similar studies have gone: Previous research in cardiac rehabilitation supports exercise-based strategies to improve functional outcomes, though this specific isometric handgrip approach is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male patients aged 40-55 years
* Ejection fraction (EF) \>40% as documented by pre-operative echocardiography
* Patients undergoing elective open-heart surgery via median sternotomy (e.g., CABG, single or double valve replacement)
* Cognitive ability to follow exercise instructions
* Sternal stability with no evidence of post-operative sternal complications
* Hemodynamically stable for at least 24-48 hours postoperatively
* Stable cardiac rhythm (sinus rhythm or well-controlled atrial fibrillation with resting heart rate \<100 bpm)

Exclusion Criteria:

* Sternal infection or wound complications
* Medically unstable postoperative condition preventing safe participation in exercise training
* Musculoskeletal or cognitive impairments limiting ability to participate in exercise training
* Previous cardiac surgery
* Anemia
* Uncontrolled hypertension
* Cardiac arrhythmia or angina

Where it's running

  • National Heart institute
    Giza, Egypt
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.