Measuring functional proteins in women with polycystic ovary syndrome
Assessment of the Concentrations of Functional Proteins as Potential Early Markers of Insulin Resistance in Women With Polycystic Ovary Syndrome
This study is trying to see if measuring certain proteins in women with polycystic ovary syndrome can help identify those with insulin resistance and improve early diagnosis and treatment options.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Jagiellonian University Academic / other |
| Locations | 1 site (Krakow) |
| Trial ID | NCT06793098 on ClinicalTrials.gov |
What this trial studies
This observational study aims to measure and compare the concentrations of functional proteins such as kisspeptin, ghrelin, and zonulin in women with polycystic ovary syndrome (PCOS) who have insulin resistance, those with PCOS without insulin resistance, and women without PCOS. The study seeks to identify potential markers of insulin resistance that could be used for early diagnosis and intervention. By utilizing simpler diagnostic methods like HOMA-IR and fasting insulin measurements, the research aims to enhance understanding of the metabolic disturbances associated with PCOS and their long-term health implications.
Who should consider this trial
Good fit: Ideal candidates for this study are women aged 18-45 years who have been diagnosed with polycystic ovary syndrome.
Not a fit: Patients who have had at least one ovary removed or those with treated diabetes or metabolic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier diagnosis and treatment of insulin resistance in women with PCOS, potentially reducing the risk of serious health complications.
How similar studies have performed: While the approach of identifying metabolic markers in PCOS is being explored, this specific methodology and focus on functional proteins is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * women aged 18-45 years Exclusion Criteria: * removal of at least one ovary * treated diabetes of any type * diagnosed and treated metabolic diseases * diagnosed and treated autoimmune diseases * diagnosed and treated autoinflammatory diseases
Where this trial is running
Krakow
- Jagiellonian University — Krakow, Poland (Recruiting)
Study contacts
- Study coordinator: Iwona Gawron, Ph.D., M.D.
- Email: iwona.gawron@uj.edu.pl
- Phone: +48 124248570
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.