Measuring Exhaled Gas Temperature to See if Passive Humidification Keeps Air Humid for Intubated Patients
Official title: Measurement of Expiratory Gas Temperature in Intubated Patients to Estimate Expiratory Absolute Humidity
Run by Laval University · NCT07420673 · Data updated 2026-11-12
This study tests whether measuring the temperature of exhaled air in intubated ICU patients who use passive humidification can help estimate the humidity delivered to the lungs.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | Laval University Academic / other |
| Locations | 1 site (Québec, Quebec) |
| Status | Recruiting |
| Started | May 25, 2026 |
| Main results expected | December 2027 |
| Study ends | June 2028 |
| Registry record updated | November 5, 2026 |
| Trial ID | NCT07420673 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 and older who are intubated and on mechanical ventilation with passive humidification in the ICU.
✕Probably not a fit
Patients not using passive humidification or with incompatible ventilation settings may not benefit from this measurement approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In intubated ICU patients, keeping the air moist is important to prevent thick secretions. This observational study will measure the temperature of exhaled gases to estimate absolute humidity during expiration. The goal is to better reproduce real clinical conditions in bench testing and to improve how heat and moisture exchangers are evaluated. Data from these measurements may help standardize humidification assessments across different patient temperatures and body states.
Why it matters
Potential benefit: If successful, the results could improve bench tests and device evaluations for humidification devices, leading to more accurate matching of humidification to patient needs.
How similar studies have gone: Previous work suggests a relationship between expiratory temperature and humidity, but data for awake/ICU patients are limited and more validation is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults (≥18 years) * Intubated and mechanically ventilated in the intensive care unite * Using passive humidification (Heat and Moisture exchanger) Exclusion Criteria: * PEEP set \< 12 cmH₂O * Inhaled nitric oxide therapy * Tracheostomy
Where it's running
-
Insitut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval
Québec, Quebec, Canada Recruiting
Study contacts
- Study coordinator: Francois Lellouche, MD, PhD
- Email: francois.lellouche@criucpq.ulaval.ca
- Phone: 1 418-656-8711
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Early switch from controlled to assisted ventilation for critically ill adults
This trial will try switching stable adult ICU patients who are on controlled mechanical ventilation to assisted ventilation within 6 hours of eligibility to see if more of them are successfully taken off the ventilator by day 28.
-
D-RSBI vs RSBI to predict weaning success in COPD patients
This study tests whether diaphragmatic rapid shallow breathing index (D-RSBI) can better predict which COPD patients on mechanical ventilation will successfully wean than the traditional RSBI.
-
Predicting extubation failure in ICU patients using a physiotherapy assessment
This study is trying to see if a physiotherapy assessment can help predict which ICU patients on a ventilator might struggle after being taken off the machine.
-
Training respiratory muscles during neck flexion for patients on mechanical ventilation
This study tests if combining breathing exercises with neck flexion can help patients on mechanical ventilation strengthen their respiratory muscles and successfully wean off the ventilator.
-
Assessing readiness for extubation in brain-injured patients
This study is testing a new way to see if brain-injured patients are ready to be taken off a breathing machine to help them recover better and avoid complications.
-
Breathlessness during ventilator weaning in obese ICU patients
This project will measure how often and how severe breathlessness is when obese ICU patients try to breathe on their own during ventilator weaning.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.