Measuring absolute brain blood flow and microcirculation with continuous thermodilution
Official title: Measuring Absolute Brain Flow and Brain Microcirculation Resistance by Continuous Thermodilution: a Pilot Study - RESISTANCE
Run by Centre Hospitalier Universitaire de Nice · NCT07566598 · Data updated 2026-11-12
We will use a catheter thermodilution method to measure brain blood flow and microvascular resistance in adults who had a successful mechanical thrombectomy for a middle cerebral artery stroke to see if we can obtain reliable absolute flow measurements.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 15 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes-maritimes) |
| Status | Recruiting |
| Started | April 7, 2026 |
| Main results expected | May 2027 |
| Study ends | November 2027 |
| Registry record updated | May 13, 2026 |
| Trial ID | NCT07566598 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–80 hospitalized at CHU de Nice for ischemic stroke from middle cerebral artery thrombosis who consent and have achieved TICI 2c or 3 perfusion after mechanical thrombectomy are ideal candidates.
✕Probably not a fit
Patients who did not achieve TICI 2c/3 reperfusion, have very small vessel diameters (<1 mm), severe organ failure, infection, pregnancy, legal incapacity, or who cannot cooperate are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center interventional protocol enrolls adults (18–80) hospitalized for ischemic stroke due to middle cerebral artery thrombosis who achieved TICI 2c or 3 reperfusion after mechanical thrombectomy. After recanalization, a continuous thermodilution technique via endovascular catheter is used to obtain absolute cerebral blood flow and calculate microvascular resistance. Collected measurements will be compared across participants to characterize post-thrombectomy microcirculatory status. The goal is to generate physiological data that may link microvascular parameters with clinical outcomes after reperfusion.
Why it matters
Potential benefit: If successful, this approach could help identify patients with poor microcirculation after thrombectomy and guide treatments to improve recovery.
How similar studies have gone: Thermodilution methods have been applied successfully in coronary circulation, but using continuous thermodilution to measure absolute cerebral flow and microvascular resistance is relatively novel with limited prior data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men or women aged 18 to 80 * Social Security beneficiaries * Obtained signed consent to participate in the study * TICI 2c or TICI 3 score after mechanical thrombectomy * Patients hospitalized for ischemic stroke due to middle cerebral artery thrombosis Exclusion Criteria: * Spasm of an artery without significant stenosis * Vessel diameter less than 1 mm * Severe visceral failure * Local infection * Minors * Adults protected by law * Patients deprived of their liberty * Subjects who are uncooperative or unable to meet the requirements of the protocol * Subjects participating in another clinical trial or in a period of exclusion from a previous clinical trial * Pregnant women
Where it's running
-
CHU de NICE
Nice, Alpes-maritimes, France Recruiting
Study contacts
- Study coordinator: Yves CHAU, MD
- Email: chau.hd@chu-nice.fr
- Phone: +33 4 92 03 35 90
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.