Measuring absolute brain blood flow and microcirculation with continuous thermodilution
Measuring Absolute Brain Flow and Brain Microcirculation Resistance by Continuous Thermodilution: a Pilot Study - RESISTANCE
We will use a catheter thermodilution method to measure brain blood flow and microvascular resistance in adults who had a successful mechanical thrombectomy for a middle cerebral artery stroke to see if we can obtain reliable absolute flow measurements.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes-maritimes) |
| Trial ID | NCT07566598 on ClinicalTrials.gov |
What this trial studies
This single-center interventional protocol enrolls adults (18–80) hospitalized for ischemic stroke due to middle cerebral artery thrombosis who achieved TICI 2c or 3 reperfusion after mechanical thrombectomy. After recanalization, a continuous thermodilution technique via endovascular catheter is used to obtain absolute cerebral blood flow and calculate microvascular resistance. Collected measurements will be compared across participants to characterize post-thrombectomy microcirculatory status. The goal is to generate physiological data that may link microvascular parameters with clinical outcomes after reperfusion.
Who should consider this trial
Good fit: Adults aged 18–80 hospitalized at CHU de Nice for ischemic stroke from middle cerebral artery thrombosis who consent and have achieved TICI 2c or 3 perfusion after mechanical thrombectomy are ideal candidates.
Not a fit: Patients who did not achieve TICI 2c/3 reperfusion, have very small vessel diameters (<1 mm), severe organ failure, infection, pregnancy, legal incapacity, or who cannot cooperate are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this approach could help identify patients with poor microcirculation after thrombectomy and guide treatments to improve recovery.
How similar studies have performed: Thermodilution methods have been applied successfully in coronary circulation, but using continuous thermodilution to measure absolute cerebral flow and microvascular resistance is relatively novel with limited prior data.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men or women aged 18 to 80 * Social Security beneficiaries * Obtained signed consent to participate in the study * TICI 2c or TICI 3 score after mechanical thrombectomy * Patients hospitalized for ischemic stroke due to middle cerebral artery thrombosis Exclusion Criteria: * Spasm of an artery without significant stenosis * Vessel diameter less than 1 mm * Severe visceral failure * Local infection * Minors * Adults protected by law * Patients deprived of their liberty * Subjects who are uncooperative or unable to meet the requirements of the protocol * Subjects participating in another clinical trial or in a period of exclusion from a previous clinical trial * Pregnant women
Where this trial is running
Nice, Alpes-maritimes
- CHU de NICE — Nice, Alpes-maritimes, France (Recruiting)
Study contacts
- Study coordinator: Yves CHAU, MD
- Email: chau.hd@chu-nice.fr
- Phone: +33 4 92 03 35 90
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.