Matrix Rhythm Therapy for Carpal Tunnel Syndrome
Official title: Effectiveness of Matrix Rhythm Therapy on Symptom Severity and Function in Carpal Tunnel Syndrome: A Randomized, Placebo-Controlled, Assessor-Blinded Trial
Run by Izmir Bakircay University · NCT07660913 · Data updated 2026-11-12
This study tests whether adding Matrix Rhythm Therapy to standard care helps people with mild-to-moderate carpal tunnel syndrome improve symptoms, hand function, grip and pinch strength, and quality of life.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 84 (estimated) |
| Sponsor | Izmir Bakircay University Academic / other |
| Locations | 1 site (Izmir) |
| Status | Recruiting |
| Started | July 1, 2026 |
| Main results expected | July 1, 2027 |
| Study ends | September 1, 2027 |
| Registry record updated | July 8, 2026 |
| Trial ID | NCT07660913 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with unilateral mild-to-moderate carpal tunnel syndrome confirmed by clinical exam and EMG, with symptoms for at least 12 weeks, and adequate cognitive and literacy abilities.
✕Probably not a fit
Individuals with prior carpal tunnel release, recent corticosteroid injections, recent physiotherapy for CTS, other upper limb neurological issues, or other hand/wrist surgeries may not benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares Matrix Rhythm Therapy with sham therapy and conventional physiotherapy in adults with unilateral mild-to-moderate carpal tunnel syndrome persisting at least 12 weeks. Participants are randomized to receive active Matrix Rhythm Therapy, a sham treatment, or conservative physiotherapy, in addition to usual care. Outcomes include symptom severity, hand function, grip and pinch strength, and quality of life, measured to see if the therapy offers additional benefit over standard treatment.
Why it matters
Potential benefit: If effective, Matrix Rhythm Therapy could provide additional relief from symptoms and improve hand function for people with carpal tunnel syndrome.
How similar studies have gone: Previous research in similar approaches has shown mixed results; this study explores a targeted rhythm-based therapy in CTS.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having a diagnosis of unilateral carpal tunnel syndrome confirmed by an orthopedist based on clinical examination and electromyography (EMG) testing. * Being classified with mild-to-moderate carpal tunnel syndrome severity. * Having symptoms persisting for at least 12 weeks. * Having a Mini-Mental State Examination (MMSE) score greater than 24. * Being literate (able to read and write). Exclusion Criteria: * History of prior carpal tunnel release surgery. * History of corticosteroid injection into the affected hand/wrist. * Having received physiotherapy for carpal tunnel syndrome within the last 6 months. * Presence of any neurological signs or symptoms in the upper extremity other than carpal tunnel syndrome. * History of prior surgery in the hand or wrist region due to other conditions. * Diagnosis of any systemic neurological disease. * Diagnosis of rheumatic diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus). * Having ongoing pain in the arm or hand due to any other underlying cause.
Where it's running
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Izmir Bakircay University
Izmir, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Ertan Şahinoğlu, PhD
- Email: ertan.sahinoglu@bakircay.edu.tr
- Phone: +90 232 493 00 00
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Carpal tunnel release vs placebo surgery in Finland
In this trial, people with carpal tunnel syndrome are randomly assigned to either standard carpal tunnel surgery or a pretend surgery to see if relief comes from the operation itself or from placebo effects.
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This trial will test whether high-intensity laser therapy helps adults 18–65 with mild-to-moderate carpal tunnel syndrome reduce pain and improve nerve function and hand strength compared with a sham procedure.
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A mix of vitamins to help recovery after carpal tunnel surgery
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This test looks at whether people with carpal tunnel syndrome whose symptoms spread beyond the usual finger area have higher central pain sensitivity, using a questionnaire and pressure pain testing.
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This study is testing if using ultrasound can help doctors diagnose and manage carpal tunnel syndrome better than the usual nerve tests.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.