Symptom spread and pain sensitivity in carpal tunnel syndrome
Official title: Evaluation of Central Sensitization Parameters Based on Extra Median Symptom Distribution in Carpal Tunnel Syndrome: A Cross-sectional Study
Run by Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey · NCT07114913 · Data updated 2026-11-12
This test looks at whether people with carpal tunnel syndrome whose symptoms spread beyond the usual finger area have higher central pain sensitivity, using a questionnaire and pressure pain testing.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey Academic / other |
| Locations | 1 site (Istanbul, Usküdar) |
| Status | Recruiting |
| Started | June 21, 2025 |
| Main results expected | January 1, 2026 |
| Study ends | March 1, 2026 |
| Registry record updated | August 11, 2025 |
| Trial ID | NCT07114913 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are literate adults aged 18–65 with clinically and electrodiagnostically confirmed carpal tunnel syndrome who consent to participate and have not had recent CTS injection or surgery.
✕Probably not a fit
Patients with diabetes, systemic inflammatory disease, other neuropathies or radiculopathy, recent CTS injection or surgery, active infection or malignancy, or those outside the 18–65 age range are unlikely to benefit from enrollment.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Carpal tunnel syndrome usually causes numbness and tingling in the thumb, index, and middle fingers, but some patients report symptoms that extend beyond the median nerve territory. This observational study compares patients with typical median-only symptoms to those with extra-median symptom distribution. Researchers will confirm diagnosis with nerve conduction studies and ultrasound, and then measure central sensitization with the Central Sensitization Inventory and pressure pain thresholds. The hypothesis is that extra-median symptom patients will show higher CSI scores and lower pressure pain thresholds, which could indicate greater central nervous system involvement and inform more personalized treatment approaches.
Why it matters
Potential benefit: If successful, the findings could help identify patients who might benefit from treatments targeted at central pain mechanisms rather than only peripheral nerve decompression.
How similar studies have gone: Previous studies have suggested a link between extra-median symptom spread and central sensitization, but evidence is limited and findings remain preliminary.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Having been diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings * Being between 18 and 65 years of age * Being literate * Agreeing to participate in the study Exclusion Criteria: * Having a history of concomitant diabetes, systemic inflammatory disease, active infection, or malignancy * Being \<18 and \>65 years of age * Being illiterate * Refusing to participate in the study * Having a disease associated with neuropathic pain, such as polyneuropathy, radiculopathy, or multiple sclerosis * History of injection or surgery for CTS within the last 6 months
Where it's running
-
Sultan Abdülhamid Han Training and Research Hospital
Istanbul, Usküdar, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Feyza Nur Yücel, Specialist
- Email: dr.fny28@gamil.com
- Phone: (0216) 542 20 00
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Matrix Rhythm Therapy for Carpal Tunnel Syndrome
This study tests whether adding Matrix Rhythm Therapy to standard care helps people with mild-to-moderate carpal tunnel syndrome improve symptoms, hand function, grip and pinch strength, and quality of life.
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In this trial, people with carpal tunnel syndrome are randomly assigned to either standard carpal tunnel surgery or a pretend surgery to see if relief comes from the operation itself or from placebo effects.
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This trial will test whether high-intensity laser therapy helps adults 18–65 with mild-to-moderate carpal tunnel syndrome reduce pain and improve nerve function and hand strength compared with a sham procedure.
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This trial tests whether combining ultrasound-guided partial release of the transverse carpal ligament with dextrose (D5W) hydrodissection provides better symptom relief for adults with carpal tunnel syndrome and at least moderate symptoms.
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A mix of vitamins to help recovery after carpal tunnel surgery
This will test whether taking alpha-lipoic acid, vitamin E, and B vitamins helps adults recover better after carpal tunnel release surgery.
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Boswellia serrata for pain sensitivity and pain modulation in healthy adults
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.