A mix of vitamins to help recovery after carpal tunnel surgery
Effect of Oral Alpha-Lipoic Acid, Vitamin E, and Vitamin B Combination on Symptoms and Function in Carpal Tunnel Syndrome Following Carpal Tunnel Surgery
This will test whether taking alpha-lipoic acid, vitamin E, and B vitamins helps adults recover better after carpal tunnel release surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospital Universiti Sains Malaysia Academic / other |
| Locations | 1 site (Kubang Kerian, Kelantan) |
| Trial ID | NCT07312123 on ClinicalTrials.gov |
What this trial studies
This randomized interventional study will assign adults with symptomatic carpal tunnel syndrome who are scheduled for carpal tunnel release to receive either an oral combination of alpha-lipoic acid, vitamin E, and B-complex or a comparator. Participants will take the assigned oral regimen around the time of surgery and be followed for changes in hand symptoms, function, and safety outcomes. The combination is chosen for its antioxidant, anti-inflammatory, and nerve-protective properties that may reduce nerve irritation and support recovery. The goal is to see if the supplement mix leads to greater symptom relief and improved hand function after surgery compared with the comparator.
Who should consider this trial
Good fit: Adults over 18 with clinical carpal tunnel syndrome who are scheduled for carpal tunnel release and can attend the Malaysian study site are ideal candidates.
Not a fit: People who are pregnant or breastfeeding, have prior trauma to the dominant hand, do not have CTS, or are not undergoing surgery are unlikely to receive benefit from this intervention.
Why it matters
Potential benefit: If successful, the supplement combination could reduce numbness and pain and speed recovery of hand function after surgery.
How similar studies have performed: Small trials of alpha-lipoic acid and B vitamins in peripheral neuropathy and some CTS studies have shown mixed but occasionally positive symptom improvements, so the approach has some supportive but not definitive prior evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than 18 years old * Subjects with symptoms and physical examination of CTS * Patients with CTS going for CT release Exclusion Criteria: * Pregnant or breast-feeding women * Patients with history of trauma in the dominant hand
Where this trial is running
Kubang Kerian, Kelantan
- Hospital Pakar Universiti Sains Malaysia — Kubang Kerian, Kelantan, Malaysia (Recruiting)
Study contacts
- Principal investigator: nurhakim bin ibrahim — Hospital Pakar Universiti Sains Malaysia
- Study coordinator: Nurhakim Bin Ibrahim, MBBCH
- Email: nurhakimibrahim@gmail.com
- Phone: +60123170898
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.