A mix of vitamins to help recovery after carpal tunnel surgery
Official title: Effect of Oral Alpha-Lipoic Acid, Vitamin E, and Vitamin B Combination on Symptoms and Function in Carpal Tunnel Syndrome Following Carpal Tunnel Surgery
Run by Hospital Universiti Sains Malaysia · NCT07312123 · Data updated 2026-11-12
This will test whether taking alpha-lipoic acid, vitamin E, and B vitamins helps adults recover better after carpal tunnel release surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 84 (estimated) |
| Sponsor | Hospital Universiti Sains Malaysia Academic / other |
| Locations | 1 site (Kubang Kerian, Kelantan) |
| Status | Recruiting |
| Started | December 8, 2025 |
| Main results expected | December 8, 2026 |
| Study ends | January 31, 2027 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT07312123 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with clinical carpal tunnel syndrome who are scheduled for carpal tunnel release and can attend the Malaysian study site are ideal candidates.
✕Probably not a fit
People who are pregnant or breastfeeding, have prior trauma to the dominant hand, do not have CTS, or are not undergoing surgery are unlikely to receive benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized interventional study will assign adults with symptomatic carpal tunnel syndrome who are scheduled for carpal tunnel release to receive either an oral combination of alpha-lipoic acid, vitamin E, and B-complex or a comparator. Participants will take the assigned oral regimen around the time of surgery and be followed for changes in hand symptoms, function, and safety outcomes. The combination is chosen for its antioxidant, anti-inflammatory, and nerve-protective properties that may reduce nerve irritation and support recovery. The goal is to see if the supplement mix leads to greater symptom relief and improved hand function after surgery compared with the comparator.
Why it matters
Potential benefit: If successful, the supplement combination could reduce numbness and pain and speed recovery of hand function after surgery.
How similar studies have gone: Small trials of alpha-lipoic acid and B vitamins in peripheral neuropathy and some CTS studies have shown mixed but occasionally positive symptom improvements, so the approach has some supportive but not definitive prior evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age more than 18 years old * Subjects with symptoms and physical examination of CTS * Patients with CTS going for CT release Exclusion Criteria: * Pregnant or breast-feeding women * Patients with history of trauma in the dominant hand
Where it's running
-
Hospital Pakar Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia Recruiting
Study contacts
- Principal investigator: nurhakim bin ibrahim — Hospital Pakar Universiti Sains Malaysia
- Study coordinator: Nurhakim Bin Ibrahim, MBBCH
- Email: nurhakimibrahim@gmail.com
- Phone: +60123170898
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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In this trial, people with carpal tunnel syndrome are randomly assigned to either standard carpal tunnel surgery or a pretend surgery to see if relief comes from the operation itself or from placebo effects.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.