Ultrasound-guided needle release plus dextrose (D5W) hydrodissection for carpal tunnel syndrome
Official title: Efficacy of Combining Ultrasound-Guided Needle Release of Transverse Carpal Ligament and Median Nerve Dextrose Water Hydrodissection for Carpal Tunnel Syndrome
Run by Shin Kong Wu Ho-Su Memorial Hospital · NCT07324005 · Data updated 2026-11-12
This trial tests whether combining ultrasound-guided partial release of the transverse carpal ligament with dextrose (D5W) hydrodissection provides better symptom relief for adults with carpal tunnel syndrome and at least moderate symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 102 (estimated) |
| Sponsor | Shin Kong Wu Ho-Su Memorial Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Status | Recruiting |
| Started | January 1, 2026 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2030 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT07324005 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20–80 with clinical and electrodiagnostic confirmation of carpal tunnel syndrome, a pain/paresthesia NRS of 3 or higher, and symptoms lasting at least three months.
✕Probably not a fit
Patients with polyneuropathy, thoracic outlet syndrome, brachial plexopathy, inflammatory arthropathy, CTS onset during pregnancy or hypothyroidism, prior corticosteroid injection or wrist surgery, hypersensitivity to dextrose, or wrist anatomy unsuitable for needle release are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with clinically and electrodiagnostically confirmed carpal tunnel syndrome and persistent symptoms will receive one of three ultrasound-guided interventions: D5W perineural hydrodissection alone, ultrasound-guided partial release of the transverse carpal ligament with D5W injected to the ligament, or partial release plus D5W perineural hydrodissection. Procedures are performed under ultrasound guidance and outcomes will include symptom/pain scores and electrodiagnostic measures collected during follow-up. Key exclusions include alternative neuropathies, prior wrist surgery or corticosteroid injections, pregnancy- or hypothyroidism-onset CTS, dextrose allergy, and wrists anatomically unsuitable for needle release. The study compares the size and durability of symptom and functional improvements across the three techniques.
Why it matters
Potential benefit: If successful, the combined minimally invasive approach could offer longer-lasting symptom relief and improved nerve function without open surgery.
How similar studies have gone: Previous studies have reported longer-term benefits for D5W and PRP compared with corticosteroids and some promise for percutaneous transverse carpal ligament release, but the combination of needle release with D5W hydrodissection is relatively novel and not well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age between 20 to 80 years old * diagnosed with CTS on the basis of clinical condition and an electrophysiological analysis * the NRS of pain or paresthesia≧3 * with symptoms lasting for a minimum of 3 months. Exclusion Criteria: * history of polyneuropathy, thoracic outlet syndrome, brachial plexopathy, or inflammatory arthropathy * onset of CTS during pregnancy, hypothyroidism, or systemic infection * previous corticosteroid injection or wrist surgery for CTS * hypersensitivity to dextrose injection * the anatomic structure of the wrist is not suitable for needle release of TCL.
Where it's running
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Shin Kong Wu Ho-Su Memorial Hospital
Taipei, Taiwan Recruiting
Study contacts
- Principal investigator: Lin-Fen Hsieh — Shin Kong Wu Ho-Su Memorial Hospital
- Study coordinator: Lin-Fen Hsieh
- Email: M001026@ms.skh.org.tw
- Phone: +886-28332211
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.