Liposome-based nerve block to improve recovery after VATS lung surgery
Official title: Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Postoperative Quality of Recovery in Patients Undergoing Video-assisted Thoracoscopic Partial Pneumonectomy
Run by Sanming First Hospital · NCT07512635 · Data updated 2026-11-12
This study tests whether a preoperative intercostal nerve block with liposomal bupivacaine helps people recover better after VATS partial pneumonectomy.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 96 (estimated) |
| Sponsor | Sanming First Hospital Academic / other |
| Locations | 1 site (Sanming, Fujian) |
| Status | Recruiting |
| Started | April 6, 2026 |
| Main results expected | April 7, 2027 |
| Study ends | April 30, 2027 |
| Registry record updated | June 18, 2026 |
| Trial ID | NCT07512635 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18-65 scheduled for thoracoscopic partial pneumonectomy (ASA I-II) without local anesthetic allergy or chronic opioid use.
✕Probably not a fit
Patients with contraindications to nerve blocks, coagulation disorders, active infection at the puncture site, language barriers, or those who do not fit the ASA I-II criteria may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In patients undergoing video-assisted thoracoscopic partial pneumonectomy, the investigators compare a liposomal bupivacaine intercostal nerve block to a conventional bupivacaine block. The goal is to see if the long-acting formula improves overall recovery, reduces pain, and lowers opioid use, measured by the QoR-15 score at 24 hours post-surgery. The trial is phase 4 and interventional, with adults aged 18-65 and ASA I-II undergoing thoracic surgery. Outcomes focus on postoperative recovery quality, analgesia, and safety of the nerve block regimen.
Why it matters
Potential benefit: If successful, patients may experience better early recovery and less pain after chest surgery.
How similar studies have gone: Prior local anesthetic blocks have shown pain relief, and liposomal formulations aim to extend this effect; this study builds on existing approaches with a longer-acting option.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients scheduled for thoracic surgery under general anesthesia via thoracoscopic approach; * Age 18-65 years; * Classified as Grade I-II by the American Society of Anesthesiologists (ASA). Exclusion Criteria: * History of local anesthetic allergy. * Chronic opioid users. * Contraindications for nerve block, including infection at the puncture site and coagulation disorders; * Language communication impairment. * Other conditions unsuitable for inclusion in the trial.
Where it's running
-
SanMing First Hospital
Sanming, Fujian, China Recruiting
Study contacts
- Principal investigator: Huifen Lin, MD — No. 15, Liedong Street, Sanyuan District, Sanming City, Fujian Province
- Study coordinator: Huifen Lin, MD
- Email: smyhb0598@163.com
- Phone: (0598)8803263
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.