Clinical trial Recruiting at 1 site Phase 4 Interventional Ages 18 to 65

Liposome-based nerve block to improve recovery after VATS lung surgery

Official title: Effect of Intercostal Nerve Block With Liposomal Bupivacaine on Postoperative Quality of Recovery in Patients Undergoing Video-assisted Thoracoscopic Partial Pneumonectomy

Run by Sanming First Hospital · NCT07512635 · Data updated 2026-11-12

This study tests whether a preoperative intercostal nerve block with liposomal bupivacaine helps people recover better after VATS partial pneumonectomy.

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Quick facts

PhasePhase 4
Study typeInterventional
Ages18 Years to 65 Years
SexAll
Enrollment96 (estimated)
SponsorSanming First Hospital
Academic / other
Locations1 site (Sanming, Fujian)
StatusRecruiting
StartedApril 6, 2026
Main results expectedApril 7, 2027
Study endsApril 30, 2027
Registry record updatedJune 18, 2026
Trial IDNCT07512635 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18-65 scheduled for thoracoscopic partial pneumonectomy (ASA I-II) without local anesthetic allergy or chronic opioid use.

Probably not a fit

Patients with contraindications to nerve blocks, coagulation disorders, active infection at the puncture site, language barriers, or those who do not fit the ASA I-II criteria may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In patients undergoing video-assisted thoracoscopic partial pneumonectomy, the investigators compare a liposomal bupivacaine intercostal nerve block to a conventional bupivacaine block. The goal is to see if the long-acting formula improves overall recovery, reduces pain, and lowers opioid use, measured by the QoR-15 score at 24 hours post-surgery. The trial is phase 4 and interventional, with adults aged 18-65 and ASA I-II undergoing thoracic surgery. Outcomes focus on postoperative recovery quality, analgesia, and safety of the nerve block regimen.

Why it matters

Potential benefit: If successful, patients may experience better early recovery and less pain after chest surgery.

How similar studies have gone: Prior local anesthetic blocks have shown pain relief, and liposomal formulations aim to extend this effect; this study builds on existing approaches with a longer-acting option.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients scheduled for thoracic surgery under general anesthesia via thoracoscopic approach;
* Age 18-65 years;
* Classified as Grade I-II by the American Society of Anesthesiologists (ASA).

Exclusion Criteria:

* History of local anesthetic allergy.
* Chronic opioid users.
* Contraindications for nerve block, including infection at the puncture site and coagulation disorders;
* Language communication impairment.
* Other conditions unsuitable for inclusion in the trial.

Where it's running

  • SanMing First Hospital
    Sanming, Fujian, China
    Recruiting

Study contacts

  • Principal investigator: Huifen Lin, MD — No. 15, Liedong Street, Sanyuan District, Sanming City, Fujian Province
  • Study coordinator: Huifen Lin, MD
  • Email: smyhb0598@163.com
  • Phone: (0598)8803263

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.