Liposomal bupivacaine via transversus abdominis plane block to reduce pain after laparoscopic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center interventional trial at Beijing Tiantan Hospital compares standard bupivacaine TAP blocks with liposomal bupivacaine plus bupivacaine administered under ultrasound guidance in adults undergoing elective laparoscopic cholecystectomy, hernia repair, or appendectomy. Eligible participants are 18–64 years old with ASA physical status I–III and able to provide informed consent. The trial focuses on postoperative analgesia and safety, measuring pain scores, opioid consumption, and adverse events during the immediate postoperative period. Participants receive standardized general anesthesia and perioperative care while outcomes and complications are recorded.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled for elective laparoscopic cholecystectomy, hernia repair, and appendectomy under general anesthesia;
2. Ages 18 to 64 years old；
3. American Society of Anesthesiologists (ASA) physical status of I-III；
4. Glasgow Coma Scale (GCS) score of 15；
5. Patients must be able to understand the nature and potential personal consequences of the clinical trial, signing of the informed consent form.

Exclusion Criteria:

1. History of chronic pain syndrome of any cause.
2. Patients with heart conduction block (sinus block or atrioventricular block).
3. Patients with unstable coronary artery disease.
4. Patients with gastric ulcer or gastric bleeding.
5. Patients with diabetes and are being treated with insulin.
6. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.
7. Patients with abnormal liver function: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN.
8. Patients with renal impairment (serum creatinine \> 176 µmol/L) or receiving dialysis treatment within 28 days before surgery.
9. Patients with a history of diagnosed mental illness or currently taking psychotropic medication.
10. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.
11. Pregnancy or breastfeeding.
12. Extreme body mass index (BMI) (\< 15 or \> 35).
13. Participation in another interventional trial that interferes with the intervention or outcome of this trial.
14. Patients with a history of allergy to local anaesthetics or one of the study drugs.

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: +86 13611326978

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Liposomal bupivacaine TAP block to reduce pain after laparoscopic gynecologic cancer surgery

  This trial will test whether a long‑acting liposomal form of bupivacaine given as a transversus abdominis plane (TAP) block reduces postoperative pain for adults having laparoscopic gynecologic oncology surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07458295

• Liposomal bupivacaine for pain after laparoscopic surgery

  This trial will test whether a long-acting, liposomal form of bupivacaine given at the incision reduces postoperative pain and the need for oral pain medicines in adults having elective laparoscopic procedures.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07458256

• Liposomal Bupivacaine Plus Plain Bupivacaine vs Dexamethasone Plus Plain Bupivacaine for High-Risk Pain After Supraclavicular Brachial Plexus Block

  This trial tests whether liposomal bupivacaine with plain bupivacaine can better control postoperative pain after distal radial fracture surgery in patients at high risk of severe pain, compared with dexamethasone plus plain bupivacaine.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong · NCT07665762

• Pre-incisional ropivacaine plus Diprospan for pain after laparoscopic surgery

  This study tests whether injecting ropivacaine with Diprospan before surgery reduces pain after laparoscopic gallbladder, appendix, or hernia operations compared with ropivacaine alone.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07626463

• Remimazolam and Sevoflurane: How they work together during anesthesia

  This study tests how remimazolam and sevoflurane interact during general anesthesia in adults undergoing laparoscopic surgery to see if their combined effect is stronger, the same, or weaker than expected.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07620782

• Combining SHP Block and TAP Block in Abdominal Hysterectomy for Pain Control

  This study tests whether adding a superior hypogastric plexus block to a transversus abdominis plane block can improve pain relief after abdominal hysterectomy.

  Recruiting Tanta University · Tanta, El-Gharbia · NCT07606781

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.