Liposomal bupivacaine for pain after laparoscopic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study compares local infiltration with standard bupivacaine versus a liposomal bupivacaine formulation (with bupivacaine) at the surgical incision in adults undergoing elective laparoscopic cholecystectomy, hernia repair, or appendectomy. Participants meeting inclusion criteria receive one of the study injections at the wound site during surgery and are followed through the early postoperative period for pain intensity and analgesic use. Primary measurements focus on incision pain over the first 48–72 hours and supplemental oral opioid/analgesic consumption. Safety and adverse events related to local anesthetic use are also monitored.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled for elective laparoscopic cholecystectomy, hernia repair, and appendectomy under general anesthesia;
2. Ages 18 to 64 years old；
3. American Society of Anesthesiologists (ASA) physical status of I-III；
4. Glasgow Coma Scale (GCS) score of 15；
5. Patients must be able to understand the nature and potential personal consequences of the clinical trial, signing of the informed consent form.

Exclusion Criteria:

1. History of chronic pain syndrome of any cause.
2. Patients with heart conduction block (sinus block or atrioventricular block).
3. Patients with unstable coronary artery disease.
4. Patients with gastric ulcer or gastric bleeding.
5. Patients with diabetes and are being treated with insulin.
6. Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.
7. Patients with abnormal liver function: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN.
8. Patients with renal impairment (serum creatinine \> 176 µmol/L) or receiving dialysis treatment within 28 days before surgery.
9. Patients with a history of diagnosed mental illness or currently taking psychotropic medication.
10. Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.
11. Pregnancy or breastfeeding.
12. Extreme body mass index (BMI) (\< 15 or \> 35).
13. Participation in another interventional trial that interferes with the intervention or outcome of this trial.
14. Patients with a history of allergy to local anaesthetics or one of the study drugs.

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: +86 13611326978

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Liposomal bupivacaine TAP block to reduce pain after laparoscopic gynecologic cancer surgery

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  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07458295

• Liposomal bupivacaine via transversus abdominis plane block to reduce pain after laparoscopic surgery

  This trial will test whether adding liposomal bupivacaine to an ultrasound-guided TAP block reduces postoperative pain and opioid use in adults having elective laparoscopic abdominal surgery.

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• Liposomal Bupivacaine Plus Plain Bupivacaine vs Dexamethasone Plus Plain Bupivacaine for High-Risk Pain After Supraclavicular Brachial Plexus Block

  This trial tests whether liposomal bupivacaine with plain bupivacaine can better control postoperative pain after distal radial fracture surgery in patients at high risk of severe pain, compared with dexamethasone plus plain bupivacaine.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong · NCT07665762

• Pre-incisional ropivacaine plus Diprospan for pain after laparoscopic surgery

  This study tests whether injecting ropivacaine with Diprospan before surgery reduces pain after laparoscopic gallbladder, appendix, or hernia operations compared with ropivacaine alone.

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• Remimazolam and Sevoflurane: How they work together during anesthesia

  This study tests how remimazolam and sevoflurane interact during general anesthesia in adults undergoing laparoscopic surgery to see if their combined effect is stronger, the same, or weaker than expected.

  Recruiting Pusan National University Yangsan Hospital · Yangsan · NCT07620782

• Pre-incisional ropivacaine plus triamcinolone for pain after laparoscopic surgery

  This trial tests whether injecting ropivacaine with or without triamcinolone before incision can reduce postoperative pain in adults undergoing common laparoscopic procedures like gallbladder removal, appendix removal, or hernia repair.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07591233

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.