Clinical trial Recruiting at 1 site Observational Ages 18 to 75

Investigating B Cell Functions in Gum Disease

Official title: Periodontitis and Inflammation : Biological and Clinical Approach of B Cell Role.

Run by University Hospital, Brest · NCT02833285 · Data updated 2026-11-12

This study looks at how certain immune cells called B cells behave in people with gum disease to see if they play a role in causing damage to the gums.

Quick facts

Study typeObservational
Ages18 Years to 75 Years
SexAll
Enrollment60 (estimated)
SponsorUniversity Hospital, Brest
Academic / other
Locations1 site (Brest)
StatusRecruiting
StartedMay 1, 2015
Main results expectedSeptember 2025
Study endsSeptember 2025
Registry record updatedSeptember 17, 2025
Trial IDNCT02833285 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults requiring periodontal surgery who are in good health and can provide informed consent.

Probably not a fit

Patients who are minors, pregnant, or have taken antibiotics in the last three months, as well as those with systemic diseases or ongoing orthodontic treatment, may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines the role of B lymphocytes in chronic and aggressive periodontitis, focusing on their activation and the factors they produce that contribute to tissue destruction. The research aims to analyze B cell subsets in both the blood and gum tissue of patients undergoing periodontal surgery. By understanding the inflammatory response and the involvement of B cells, the study seeks to shed light on the mechanisms underlying periodontal disease.

Why it matters

Potential benefit: If successful, this study could lead to improved understanding and management of periodontal diseases, potentially enhancing treatment strategies.

How similar studies have gone: While the specific focus on B cell subsets in periodontitis is less explored, similar studies have shown promising results in understanding immune responses in chronic inflammatory conditions.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Requiring periodontal surgery
* In good health
* Having signed consent

Exclusion Criteria:

* Minor
* Patient having taken antibiotics in the previous 3 months
* Patients with systemic diseases including chronic inflammatory disease
* Pregnancy
* orthodontic treatment ongoing

Where it's running

  • CHRU de Brest
    Brest, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.