Investigating B Cell Functions in Gum Disease
Periodontitis and Inflammation : Biological and Clinical Approach of B Cell Role.
This study looks at how certain immune cells called B cells behave in people with gum disease to see if they play a role in causing damage to the gums.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 1 site (Brest) |
| Trial ID | NCT02833285 on ClinicalTrials.gov |
What this trial studies
This observational study examines the role of B lymphocytes in chronic and aggressive periodontitis, focusing on their activation and the factors they produce that contribute to tissue destruction. The research aims to analyze B cell subsets in both the blood and gum tissue of patients undergoing periodontal surgery. By understanding the inflammatory response and the involvement of B cells, the study seeks to shed light on the mechanisms underlying periodontal disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults requiring periodontal surgery who are in good health and can provide informed consent.
Not a fit: Patients who are minors, pregnant, or have taken antibiotics in the last three months, as well as those with systemic diseases or ongoing orthodontic treatment, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of periodontal diseases, potentially enhancing treatment strategies.
How similar studies have performed: While the specific focus on B cell subsets in periodontitis is less explored, similar studies have shown promising results in understanding immune responses in chronic inflammatory conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Requiring periodontal surgery * In good health * Having signed consent Exclusion Criteria: * Minor * Patient having taken antibiotics in the previous 3 months * Patients with systemic diseases including chronic inflammatory disease * Pregnancy * orthodontic treatment ongoing
Where this trial is running
Brest
- CHRU de Brest — Brest, France (Recruiting)
Study contacts
- Principal investigator: ALARD Jean-Eric — University Hospital of Brest
- Study coordinator: ALARD Jean-Eric
- Email: jeaneric.alard@univ-brest.fr
- Phone: 0298323384
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.