Investigating B Cell Functions in Gum Disease
Official title: Periodontitis and Inflammation : Biological and Clinical Approach of B Cell Role.
Run by University Hospital, Brest · NCT02833285 · Data updated 2026-11-12
This study looks at how certain immune cells called B cells behave in people with gum disease to see if they play a role in causing damage to the gums.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 1 site (Brest) |
| Status | Recruiting |
| Started | May 1, 2015 |
| Main results expected | September 2025 |
| Study ends | September 2025 |
| Registry record updated | September 17, 2025 |
| Trial ID | NCT02833285 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults requiring periodontal surgery who are in good health and can provide informed consent.
✕Probably not a fit
Patients who are minors, pregnant, or have taken antibiotics in the last three months, as well as those with systemic diseases or ongoing orthodontic treatment, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines the role of B lymphocytes in chronic and aggressive periodontitis, focusing on their activation and the factors they produce that contribute to tissue destruction. The research aims to analyze B cell subsets in both the blood and gum tissue of patients undergoing periodontal surgery. By understanding the inflammatory response and the involvement of B cells, the study seeks to shed light on the mechanisms underlying periodontal disease.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of periodontal diseases, potentially enhancing treatment strategies.
How similar studies have gone: While the specific focus on B cell subsets in periodontitis is less explored, similar studies have shown promising results in understanding immune responses in chronic inflammatory conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Requiring periodontal surgery * In good health * Having signed consent Exclusion Criteria: * Minor * Patient having taken antibiotics in the previous 3 months * Patients with systemic diseases including chronic inflammatory disease * Pregnancy * orthodontic treatment ongoing
Where it's running
-
CHRU de Brest
Brest, France Recruiting
Study contacts
- Principal investigator: ALARD Jean-Eric — University Hospital of Brest
- Study coordinator: ALARD Jean-Eric
- Email: jeaneric.alard@univ-brest.fr
- Phone: 0298323384
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.