Combining European cohort data to find biomarkers that guide treatment for venous thromboembolism
Official title: CoMbination of Data From European Cohorts as Part of the European MORPHEUS Project [HORIZON-HLTH-2022-11-01] - "MC-MORPHEUS".
Run by University Hospital, Brest · NCT07328152 · Data updated 2026-11-12
This project combines clinical, biological and imaging data from European patient cohorts to try to find biomarkers that predict clot recurrence, bleeding, or death in people with venous thromboembolism.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 20000 (estimated) |
| Sponsor | University Hospital, Brest Academic / other |
| Locations | 1 site (Brest) |
| Status | Recruiting |
| Started | May 1, 2024 |
| Main results expected | June 30, 2024 |
| Study ends | December 30, 2029 |
| Registry record updated | January 9, 2026 |
| Trial ID | NCT07328152 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people with unprovoked venous thromboembolism who are participants in one of the cohorts led by members of the European MORPHEUS consortium and who have given consent for data use.
✕Probably not a fit
Patients who are not enrolled in the participating cohorts, who have not given consent for data sharing, or whose VTE was provoked by a clear transient cause are unlikely to benefit directly from this project.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The MORPHEUS programme brings together clinical, biological, morphological and socio-anthropological data from 14 French and European cohorts into one harmonized database. Using systematic literature review, cohort fusion and both quantitative and qualitative methods, the project will search for biomarkers that discriminate risk of thromboembolic recurrence, bleeding and mortality after venous thromboembolism. MC-MORPHEUS is the data-aggregation phase focused on identifying those predictive markers that will feed a time-dependent, multi-level prediction tool. That tool is intended to be integrated into shared medical decision-making and later validated in a randomized stepped-wedge cluster trial.
Why it matters
Potential benefit: If successful, this work could help personalize how long and which anticoagulant treatments patients receive, potentially reducing repeat clots and bleeding.
How similar studies have gone: Previous research has produced risk scores and candidate biomarkers for VTE outcomes, but large multicountry efforts combining clinical, biological, imaging and socio-anthropological data like MORPHEUS are novel and not yet validated.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Cohorts led by members of the European MORPHEUS project consortium European MORPHEUS project Exclusion Criteria: * Lack of consent in cohorts
Where it's running
-
Chu Brest
Brest, France Recruiting
Study contacts
- Study coordinator: Francis COUTURAUD
- Email: francis.couturaud@chu-brest.fr
- Phone: 298347348
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
DoACs vs LMWH for blood flow after knee replacement
This study tests whether rivaroxaban, apixaban, or LMWH work differently to support blood flow in the legs after total knee replacement in adults.
-
Prognostic value of the 2026 AHA/ACC PE classification in ED patients with acute PE
This study tests whether the 2026 AHA/ACC five-category PE classification helps predict 30-day major adverse pulmonary embolism events in adults with acute PE presenting to the ED.
-
Screening for blood clots in adults with acute heart failure
This trial tests whether a guideline-based screening approach can detect pulmonary embolism in adults admitted with acute heart failure.
-
Blood test and software to guide treatment for venous thromboembolism
This project tests whether a blood-based ctDNA test combined with a software risk score can predict if VTE will come back in adults with cancer-associated DVT or PE who have finished 3–12 months of anticoagulation.
-
Aspiration thrombectomy with the Symphony or Prodigy devices
This project will try the Symphony and Prodigy aspiration thrombectomy devices to remove arterial, venous, or pulmonary blood clots in adults.
-
Rosuvastatin to help prevent blood clots in cancer patients
This study tests whether taking rosuvastatin daily for a year can lower the chance of dangerous blood clots in people with newly diagnosed or relapsed cancer who aren’t planned to receive blood-thinning medicine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.