Clinical trial Recruiting at 1 site Observational

Combining European cohort data to find biomarkers that guide treatment for venous thromboembolism

Official title: CoMbination of Data From European Cohorts as Part of the European MORPHEUS Project [HORIZON-HLTH-2022-11-01] - "MC-MORPHEUS".

Run by University Hospital, Brest · NCT07328152 · Data updated 2026-11-12

This project combines clinical, biological and imaging data from European patient cohorts to try to find biomarkers that predict clot recurrence, bleeding, or death in people with venous thromboembolism.

More Venous Thromboembolism trials

Quick facts

Study typeObservational
SexAll
Enrollment20000 (estimated)
SponsorUniversity Hospital, Brest
Academic / other
Locations1 site (Brest)
StatusRecruiting
StartedMay 1, 2024
Main results expectedJune 30, 2024
Study endsDecember 30, 2029
Registry record updatedJanuary 9, 2026
Trial IDNCT07328152 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people with unprovoked venous thromboembolism who are participants in one of the cohorts led by members of the European MORPHEUS consortium and who have given consent for data use.

Probably not a fit

Patients who are not enrolled in the participating cohorts, who have not given consent for data sharing, or whose VTE was provoked by a clear transient cause are unlikely to benefit directly from this project.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The MORPHEUS programme brings together clinical, biological, morphological and socio-anthropological data from 14 French and European cohorts into one harmonized database. Using systematic literature review, cohort fusion and both quantitative and qualitative methods, the project will search for biomarkers that discriminate risk of thromboembolic recurrence, bleeding and mortality after venous thromboembolism. MC-MORPHEUS is the data-aggregation phase focused on identifying those predictive markers that will feed a time-dependent, multi-level prediction tool. That tool is intended to be integrated into shared medical decision-making and later validated in a randomized stepped-wedge cluster trial.

Why it matters

Potential benefit: If successful, this work could help personalize how long and which anticoagulant treatments patients receive, potentially reducing repeat clots and bleeding.

How similar studies have gone: Previous research has produced risk scores and candidate biomarkers for VTE outcomes, but large multicountry efforts combining clinical, biological, imaging and socio-anthropological data like MORPHEUS are novel and not yet validated.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Cohorts led by members of the European MORPHEUS project consortium European MORPHEUS project

Exclusion Criteria:

* Lack of consent in cohorts

Where it's running

  • Chu Brest
    Brest, France
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.