Intra-abdominal Pressure During Hernia Repair
Official title: Assessment of Intra-abdominal Pressure During the Perioperative Period of Hernia Repair
Run by Centre Hospitalier Universitaire de Nice · NCT07531615 · Data updated 2026-11-12
This study tests perioperative abdominal pressure during open midline incisional hernia repair to see how pressure relates to outcomes in adults with moderate to large defects.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 10 (estimated) |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice, Alpes-Maritimes) |
| Status | Recruiting |
| Started | July 30, 2026 |
| Main results expected | March 1, 2028 |
| Study ends | August 1, 2028 |
| Registry record updated | July 2, 2026 |
| Trial ID | NCT07531615 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with midline incisional hernias having 4–10 cm transverse defect width and EHS M2–M4 locations, undergoing elective open repair with retromuscular mesh at CHU de Nice.
✕Probably not a fit
Patients undergoing different surgical approaches, smaller or larger defects, or those not meeting inclusion criteria may not experience a benefit from these findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial examines intra-abdominal pressure measurements taken during open midline incisional hernia repairs with retromuscular mesh placement. It is an interventional, non-randomized study conducted at CHU de Nice, focusing on patients with specific defect sizes (4–10 cm) and EHS M2–M4 locations. The goal is to understand how perioperative pressure may influence recurrence risk and inform surgical technique choices. Exclusion criteria include alternative hernia types, laparoscopic approaches, pregnancy, and certain legal protections. Results could help refine techniques to reduce recurrence and complications after repair.
Why it matters
Potential benefit: If successful, the findings could guide surgeons on optimal intra-abdominal pressure targets to minimize recurrence and improve recovery after open midline incisional hernia repair.
How similar studies have gone: Previous work has explored tension-free repairs and pressure dynamics, but direct perioperative intra-abdominal pressure testing in this specific repair context remains limited, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Midline incisional hernias with a hernia defect width between 4 and 10 cm in the transverse axis, corresponding to W2 according to the EHS classification * M2, M3, and M4 locations according to the EHS classification (i.e., hernia defects located from 3 cm below the xiphoid process to 3 cm above the upper border of the pubic symphysis) * Patients scheduled for elective open midline incisional hernia repair with retromuscular mesh placement * Provision of written informed consent * Affiliation with a national health insurance system Exclusion Criteria: * Other types of incisional hernia * Minimally invasive surgery (laparoscopic or robotic approach) * Patients under legal protection (guardianship or curatorship), or patients unable to participate in a clinical study in accordance with Article L.1121-16 of the French Public Health Code * Pregnant or breastfeeding women of childbearing age
Where it's running
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CHU de Nice
Nice, Alpes-Maritimes, France Recruiting
Study contacts
- Study coordinator: Damien MASSALOU, MD PhD
- Email: massalou.d@chu-nice.fr
- Phone: +33492032264
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.