Pre‑surgery optimisation for ventral hernia repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multicentre, single-blinded, randomised trial that assigns adults with a 4–8 cm ventral hernia defect to either a multimodal preoptimisation programme or to usual care with surgery without structured preoptimisation. The preoptimisation programme includes interventions to increase physical activity, promote weight loss, and optimise treatment of comorbidities before elective repair. The primary outcome is postoperative complications measured at three months. During surgery the team will collect skin, muscle, and fascia biopsies and take blood samples before and after surgery to study molecular effects, especially on collagen metabolism.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with a ventral hernia with a defect width of at least 4 cm.
* Symptom burden related to the hernia sufficient to justify surgical intervention.
* Age ≥ 18 years.

Exclusion Criteria:

* Expected survival of less than three years.
* Inability to comprehend oral and written information or to provide informed consent.
* Acute complication of the hernia requiring emergency surgical intervention.
* General condition characterised by severe limitations in physical functional capacity.

Where it's running

• Gällivare hospital
  Gällivare, Norrbotten County, Sweden Recruiting
• Sunderby Hospital
  Luleå, Norrbotten County, Sweden Recruiting
• Umeå University Hospital
  Umeå, Västerbotten County, Sweden Recruiting
• Lycksele Hospital
  Lycksele, Västerbotten County, Sweden Not yet recruiting
• Skellefteå Hospital
  Skellefteå, Västerbotten County, Sweden Not yet recruiting

Study contacts

• Study coordinator: Gunnar Nordqvist, M.D.
• Email: gunnar.nordqvist@umu.se
• Phone: +46768227094

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Compliance-guided Closure Strategy for Large Ventral Hernia Repair

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• Pre-surgery BOTOX to help close very large ventral hernias

  This test tries a one-time image-guided BOTOX injection into the side abdominal muscles 3–7 weeks before open repair to see if it helps surgeons fully close very large ventral hernias in adults.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07220382

• PrioritiesAI: A chat tool to help older adults with hernia decide what matters most for surgery

  This study tests an AI-powered chat assistant to help people with hernia clearly express and communicate their health goals for elective surgery.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07848386

• Intra-abdominal Pressure During Hernia Repair

  This study tests perioperative abdominal pressure during open midline incisional hernia repair to see how pressure relates to outcomes in adults with moderate to large defects.

  Recruiting Centre Hospitalier Universitaire de Nice · Nice, Alpes-Maritimes · NCT07531615

• Mesh fixation for ventral hernia repair using ECLIPSIUM device

  This trial tests whether the ECLIPSIUM bioresorbable fixation system can securely hold mesh in ventral hernia repairs and reduce recurrences compared with bioresorbable tacks.

  Recruiting at 8 sites Tissium · Loma Linda, California and 11 other locations · NCT07277946

• Long-term outcomes after FETO for severe left or right congenital diaphragmatic hernia

  This trial will test whether performing FETO in fetuses with isolated severe left or right CDH helps more babies survive to hospital discharge and have fewer long-term problems than standard care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07166172

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.