Using mesh to prevent hernias after stoma closure in rectal cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of polypropylene mesh in preventing hernias after stoma closure in patients with colorectal cancer. Participants will be randomly assigned to receive either mesh or non-mesh repair techniques during their stoma closure surgery. The study will follow participants for two years to assess the incidence of parastomal hernias, wound infections, and overall quality of life. The trial will include 142 patients in total, with a focus on comparing outcomes between the two groups.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed informed consent
* Absence of distant metastases (M0)
* ECOG (Eastern Cooperative Oncology Group) status 0-2
* completed course of adjuvant treatment
* Absence of acute inflammatory parastomal complications
* Integrity of colorectal anastomosis

Exclusion Criteria:

* Inability to obtain consent to participate
* Synchronous and metachronous malignant neoplasms
* Clinically significant diseases of the cardiovascular system, liver, kidney, central nervous system
* Parastomal inflammation and other conditions that increase the risk of postoperative complications
* Pregnancy
* HIV infection

Where it's running

• N.N.Blokhin Russian Cancer Research Center
  Moscow, Russia Recruiting

Study contacts

• Study coordinator: Sergey Gordeyev, D.Sc.
• Email: ss.netoncology@gmail.com
• Phone: 9104501213

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Single vs. double stapling and purse-string techniques after rectal cancer surgery

  This trial tests whether using a single-stapling method to join the bowel after rectal cancer surgery results in fewer leaks compared with the double-stapling method.

  Recruiting Alexandria University · Alexandria · NCT07929415

• DEM301 in advanced colorectal cancer: a first-in-human test

  This first-in-human Phase 1 study tests DEM301 in adults with advanced metastatic colorectal cancer to see if it is safe, how it behaves in the body, and whether it shows any signs of activity.

  Recruiting at 2 sites Phase 1 DEM BioPharma, Inc. · Birtinya, Queensland and 1 other locations · NCT07805369

• Rectal cancer registry to track real-world treatments and outcomes

  This registry collects real-world data on how locally advanced rectal cancer is treated in Austria, to see how TNT and dMMR/MSI-H cases are managed and what outcomes occur.

  Recruiting at 2 sites Austrian Breast & Colorectal Cancer Study Group · Wiener Neustadt, Lower Austria and 5 other locations · NCT07780305

• Aerobic exercise and guided imagery for bowel problems after rectal cancer surgery

  This study tests whether a program of aerobic exercise plus guided imagery helps people with low anterior resection syndrome after rectal cancer surgery.

  Recruiting Biruni University · Istanbul · NCT07732894

• Active surveillance vs chemoradiotherapy after local removal of intermediate-risk T1 rectal cancer

  This study tests whether close follow-up alone after local removal of early rectal cancer can match the cancer control of adding chemoradiotherapy, while reducing treatment-related side effects.

  Recruiting at 2 sites Medical University of Gdansk · Limoges and 2 other locations · NCT07669298

• SIM0689 in adults with advanced solid tumors

  This study tests SIM0689 by itself to see how safe it is and how the body handles it in adults with advanced solid tumors, using a dose-escalation approach and then expanding to specific tumor types at the chosen dose.

  Recruiting at 2 sites Phase 1 Jiangsu Simcere Pharmaceutical Co., Ltd. · Fuzhou, Fujian and 5 other locations · NCT07660432

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.