International Headache Registry
Official title: International Headache and Vertigo Registration Study
Run by Second Affiliated Hospital, Zhejiang University, School of Medicine · NCT05418218 · Data updated 2026-11-12
This study is collecting information from people aged 4 to 99 who have headaches or related conditions to see how these issues affect their health and treatment over time.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 4 Years to 99 Years |
| Sex | All |
| Enrollment | 200000 (estimated) |
| Sponsor | Second Affiliated Hospital, Zhejiang University, School of Medicine Academic / other |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Status | Recruiting |
| Started | July 12, 2021 |
| Main results expected | December 31, 2082 |
| Study ends | December 31, 2082 |
| Registry record updated | May 23, 2025 |
| Trial ID | NCT05418218 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 4 to 99 years with diagnosed primary or secondary headache disorders, vertigo, or chronic pain.
✕Probably not a fit
Patients who are unable to complete headache diaries or who cannot participate in long-term follow-up may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The International Headache Registry collects data from patients aged 4 to 99 years who suffer from various headache disorders, including migraines and tension-type headaches, as well as vertigo and chronic pain conditions like fibromyalgia. This observational study aims to analyze biomarkers, imaging features, genetic characteristics, and treatment outcomes related to these conditions. Participants will undergo long-term follow-up to assess the progression and management of their symptoms. The study seeks to enhance understanding of headache-related diseases and their interconnections with other health issues.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and treatment strategies for patients suffering from headache disorders and related conditions.
How similar studies have gone: Other studies focusing on headache disorders and their biomarkers have shown promise, indicating that this approach could yield valuable insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: The following are requirements for entry into the study: 1. Written informed consent and participant privacy information (eg, Written Authorization for Use and Release of Health and Research Study Information) obtained from the participant prior to initiation of any study-specific procedures. 2. Male or female participants ages 4 to 99 years, inclusive, at Visit 1. 3. Headache patients meeting the diagnostic criteria for ICHD-3, including primary headaches such as migraine and tension tension-type headaches, secondary headaches, and patients who meet the headache diagnosis in the ICHD-3 appendix (including vestibular migraine). Exclusion Criteria: 1. Patients who were unable to complete scales such as headache diary. 2. Patients denied or unable to be admitted for long-term follow-up.
Where it's running
-
Kaiming Liu
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Principal investigator: Kaiming Liu, Doctor — headache specialist clinic of the Second Affiliated Hospital of Zhejiang Medical University
- Study coordinator: Kaiming Liu, Doctor
- Email: 2314411@zju.edu.cn
- Phone: +8615068862055
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Registry for headache and vertigo conditions in China
This study is collecting information from people of all ages who have headaches or vertigo to see how different treatments work and how these conditions relate to other health issues.
-
China Headache Disorders Registry (CHAIRS) for People with Migraine and Other Primary Headaches
This project will collect clinical, imaging, biomarker, genetic, and treatment outcome data from people aged 12 and older with primary headache disorders, including migraine and medication‑overuse headache, to see if patterns predict outcomes and guide care.
-
Remote electrical neuromodulation to test pain inhibition in migraine and fibromyalgia
We’re testing if the Nerivio wearable can boost the body’s natural pain-inhibition system (CPM) and reduce pain more than a sham device in adults with migraine or fibromyalgia.
-
Magnesium sulfate for acute non-traumatic headache in the ED: 2 g vs 4 g vs standard paracetamol
This study tests whether intravenous magnesium sulfate given in different doses helps adults with acute non-traumatic headache in the emergency department, compared with paracetamol.
-
Genetic and blood markers linked to Menière's disease and symptoms
This project will test whether common gene variants and blood markers that control inner-ear ion balance differ between people with Menière's disease, people with vestibular migraine, and people without vestibular disorders.
-
Home-based VR neurofeedback for adolescents with migraine
This program tests whether a home-based virtual reality system guided by a wearable EEG headband can help adolescents (ages 10–16) who have migraine.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.