China Headache Disorders Registry (CHAIRS) for People with Migraine and Other Primary Headaches

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The China HeadAche DIsorders Registry (CHAIRS) aims to enroll up to 10,000 patients aged 12 years and older with primary headache disorders across several tertiary hospitals in China. Participants meeting ICHD‑3 criteria will undergo standardized collection of clinical data, neuroimaging, cognitive testing, blood biomarkers, genetic information, and sociodemographic variables, while treatments and outcomes are recorded. The registry is observational and documents real‑world use of therapies (including traditional preparations and agents such as erenumab) without assigning interventions. Long‑term follow‑up is planned to define disease trajectories, identify predictors of chronification and medication‑overuse headache, and inform personalized care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age ≥ 12 years old,Any gender;
2. The first onset age of primary headache was less than 50 years old(Age \<65 years at first diagnosis of chronic migraine);
3. patients with primary headache (migraine, tension headache and other types of primary headache) or primary headache complicated with MOH according to ICHD-3;
4. Sign the informed consent form.

Exclusion Criteria:

1. According to the ICHD-3 diagnostic criteria, there are still headaches directly related to secondary factors (except drug overuse) at the time of enrollment;
2. Those who cannot be diagnosed as primary headache or primary headache combined with medication overuse headache according to ICHD-3;
3. According to DSM-V diagnostic criteria, patients with severe mental diseases (such as schizophrenia, mental disorders associated with mental retardation, etc.);
4. Patients with severe organic diseases, such as malignant tumors, and the expected survival time is less than 1 year;
5. Pregnant,planning pregnancy or Lactating women;
6. Subjects participating in other clinical trials;
7. Unable to cooperate to complete the follow-up due to geographical or other reasons

Where it's running

• Anqing Municipal Hospital
  Anqing, Anhui, China Recruiting
• The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital)
  Wuhu, Anhui, China Recruiting
• Beijing Tiantan Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Recruiting
• Beijing Chaoyang Hospital
  Beijing, Beijing Municipality, China Recruiting
• Peking University Third Hospital
  Beijing, Beijing Municipality, China Recruiting
• The First Hospital of Fangshan District, Beijing
  Beijing, Beijing Municipality, China Recruiting

+11 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Yong Gang Wang, Doctor
• Email: w100yg@163.com
• Phone: 15010066622

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• International Headache Registry

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  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05418218

• Registry for headache and vertigo conditions in China

  This study is collecting information from people of all ages who have headaches or vertigo to see how different treatments work and how these conditions relate to other health issues.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT04939922

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  This study tests whether intravenous magnesium sulfate given in different doses helps adults with acute non-traumatic headache in the emergency department, compared with paracetamol.

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• Home-based VR neurofeedback for adolescents with migraine

  This program tests whether a home-based virtual reality system guided by a wearable EEG headband can help adolescents (ages 10–16) who have migraine.

  Recruiting Children's Mercy Hospital Kansas City · Kansas City, Missouri · NCT07454798

• Using virtual reality to teach relaxation techniques for kids with headaches

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  Recruiting University of Liege · Sart Tilman, Liege · NCT06921109

• Carotid sinus massage with head-down (Trendelenburg) positioning for headache relief

  This trial tests whether carotid sinus massage while lying with your head lower than your feet can relieve migraine or tension-type headaches that started within the last 24 hours.

  Recruiting Hospital Municipal Pedro T. Orellana · Trenque Lauquen, Buenos Aires · NCT06745648

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.