Intermittent Ephedrine Boluses to Prevent Postinduction Hypotension in High-Risk Major Abdominal Surgery
Official title: Intermittent Ephedrine Boluses for Prophylaxis Against Postinduction Hypotension in High-risk Patients Undergoing Major Abdominal Surgery: a Randomized Double-blinded Controlled Trial: a Randomized Double-blinded Controlled Trial
Run by Cairo University · NCT07722013 · Data updated 2026-11-12
This trial tests whether giving small, regular ephedrine doses around induction can prevent low blood pressure after anesthesia in older, higher-risk patients undergoing major abdominal surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years and up |
| Sex | All |
| Enrollment | 124 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | August 4, 2026 |
| Main results expected | December 2026 |
| Study ends | December 2026 |
| Registry record updated | August 6, 2026 |
| Trial ID | NCT07722013 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 50 undergoing major abdominal surgery who are at high risk for hypotension and meet the specified inclusion criteria.
✕Probably not a fit
Patients with severe cardiac disease, uncontrolled hypertension, renal impairment, on vasopressors, or with contraindications to ephedrine may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study compares intermittent ephedrine boluses added to standard care against standard care alone for preventing postinduction hypotension. Fluid management includes 500 mL Ringer's boluses for responders, with up to 1500 mL total, while induction uses fentanyl/propofol and is maintained with isoflurane. Ephedrine is given at induction and every 5 minutes for 20 minutes, unless MAP is ≥80 mmHg or a vasopressor was recently used; hypotension is treated with additional ephedrine boluses as needed. Patients are selected if they are adults over 50, overweight beyond a minimum threshold, ASA I or higher, and undergoing major abdominal surgery, with several cardiovascular and renal exclusions. The trial is sponsored by Cairo University and conducted at Kasr Alainy Hospital in Cairo.
Why it matters
Potential benefit: If successful, the approach could reduce instances of postinduction hypotension and related complications in high-risk surgical patients.
How similar studies have gone: Prior research has explored vasopressor strategies for preventing intraoperative hypotension; this approach tests a specific prophylactic ephedrine regimen in a high-risk cohort.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged \>50 years, * weight \>50 kg, * American Society of Anesthesiologists (ASA) Physical Status score of \> I, * undergoing major abdominal surgery Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 40%, heart block, significant uncontrolled arrhythmias, tight stenotic valvular lesions) * Acute cardiovascular pathologies: acute/decompensated heart failure, acute coronary syndrome * Uncontrolled hypertension (systolic blood pressure\>150 mmHg) * Preoperative HR more than 110 bpm despite proper fluid management and patients with renal impairment * Renal impairment * Patients on vasopressor infusion, * Allergy of any of the study drugs
Where it's running
-
Kasr Alainy Hospital
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Maha Mostafa, MD
- Email: maha.mostafa@cu.edu.eg
- Phone: +201000365115
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.