Continuous versus bolus norepinephrine during anesthesia induction for postinduction hypotension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

INDUCT-Multi is a multicenter, randomized comparison of continuous norepinephrine infusion versus repeated bolus dosing started during induction of general anesthesia. The trial enrolls consenting patients aged 45 and older having elective major non-cardiac surgery who will have radial arterial catheter monitoring and carry predefined risk factors for acute kidney injury. Continuous arterial blood pressure monitoring is used during induction and the assigned norepinephrine strategy is applied to maintain blood pressure. The main focus is on reducing the frequency and severity of postinduction hypotension, with secondary interest in downstream organ injury such as acute kidney injury and overall hemodynamic stability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

We will include consenting patients ≥45 years scheduled for elective non-cardiac surgery under general anesthesia with planned continuous intra-arterial blood pressure monitoring with a radial arterial catheter and with at least two of the following risk criteria for developing acute kidney injury:

* Age ≥65 years
* ASA physical status III or IV
* Chronic arterial hypertension
* Diabetes mellitus requiring medication
* Intra-abdominal surgery
* Preoperative renal insufficiency (serum creatinine ≥1.2 mg/dL)

Exclusion Criteria:

* Pregnancy
* Cardiac arrhythmia
* History of intracranial hemorrhage or intracranial aneurysm
* Clinical indication for continuous norepinephrine infusion during induction of general anesthesia (e.g., severe aortic valve stenosis, coronary artery disease, or heart failure)
* Patients who are unable to understand, read, and provide informed consent in German

Where it's running

• Department of Anesthesiology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf
  Düsseldorf, Germany Recruiting
• Department of Anesthesiology, Center of Anesthesiology and Intensive Care Medicine, University Medical Center Hamburg-Eppendorf
  Hamburg, Germany Recruiting
• Department of Anaesthesiology, University Hospital LMU Munich
  München, Germany Recruiting
• Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin
  Berlin, Germany Not yet recruiting

Study contacts

• Study coordinator: Kristen K Thomsen, MD
• Email: kr.thomsen@uke.de
• Phone: +4940741070215

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.