Comparing two surgical approaches for lymphadenectomy in endometrial cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to compare the effectiveness of two surgical approaches, transvaginal paracervical and transperitoneal lymphadenectomy, during the staging surgery for endometrial cancer using the innovative V-NOTES technique. Patients diagnosed with early-stage endometrial cancer will be randomly assigned to one of the two groups to evaluate surgical and functional outcomes. The study is designed to optimize the V-NOTES technique by assessing the feasibility and outcomes of each approach in a controlled setting. It will take place at Diyarbakır Gazi Yaşargil Training and Research Hospital, a tertiary cancer treatment facility.

Why it matters

Who can join: the full rules

Patient Selection and Data Collection This study will be implemented in a single institution, Diyarbakır Gazi Yaşargil Training and Research Hospital, which functions as a tertiary cancer treatment facility.

Between March 2025 and December 2025, patients with newly diagnosed clinical early stage (FIGO 2023 stages 1 and 2) endometrial cancer who will be treated with laparoscopic surgical staging with SLN mapping at our institution will be randomized into groups. The research procedure has been approved by the ethics committee/institutional review board of Diyarbakır Gazi Yaşargil Training and Research Hospital and informed consent signed by the patient will be included in each table reviewed.

Eligible participants will be required to give informed consent to participate in the study.

Inclusion criteria will include

* Participants whose endometrial biopsy resulted in endometrial cancer and whose disease will be detected limited to the uterus using imaging modalities (computed tomography \[CT\], magnetic resonance imaging or Fluorine-18 fluorodeoxyglucose positron emission tomography/CT)
* Absence of synchronous malignancies.
* No neoadjuvant treatment before surgical intervention.

Exclusion criteria will include:

* Contraindications to using methylene blue dye or contraindications to the vNOTES procedure.
* Patients who have had previous malignancy surgery.
* Severe, deeply penetrating endometriosis or enlarged uterus that may require forced vaginal extraction
* Receiving neodajuvant therapy

Where it's running

• Gazi Yasargil Training And Research Hospital
  Diyarbakır, Baglar, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: Kevser Arkan, MD — Health Sciences University Gazi Yasargil Training and Research Hospital
• Study coordinator: Kevser Arkan, MD
• Email: kevser.toprak1989@gmail.com
• Phone: +905536476838

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.